4H-[1]苯并吡喃[3,4-d]异噁唑-4-酮的合成(英文)  

Synthesis of 4H-[1]Benzopyrano[3,4-d]isoxazol-4-ones

作　　者：邓兴国 邢媛媛[2] 王有名[2] 周正洪[2] 

机构地区：[1]湖南食品药品职业学院,湖南长沙410014 [2]南开大学元素有机化学研究所,天津300071

出　　处：《精细化工中间体》2012年第4期32-35,共4页Fine Chemical Intermediates

摘　　要：芳酰乙酸乙酯在乙氧基镁的作用下与取代的苯甲酰氯反应生成2-取代苯并吡喃酮。2-取代苯并吡喃酮和盐酸羟胺经Beckmann重排反应合成了4H-[1]苯并吡喃[3,4-d]异噁唑-4-酮。X衍射谱图表明,反应过程中表现区域选择性。对该反应的反应机理进行了初探。Ethyl benzoylacetate reacted with acetylsalicyloyl chloride in the presence of magnesium ethylate and ethyl 2-aryl-4-oxo-4H-[1]benzopyran-3-carbonate were gained,which reacted with hydroxylamine via Beckmann rearrangement and 4H-[1]benzopyrano[3,4-d]isoxazol-4-ones were gained.X-Ray analysis result of compound 2b confirmed the regioselectivity of the reaction.The mechanism of the formation of 4H-[1] benzopyrano[3,4-d]isoxazol-4-ones is also investigated.

关 键 词：苯并吡喃[3 4-d]异噁唑-4-酮 区域选择性 BECKMANN重排 机理 

分 类 号：TQ453[化学工程—农药化工]