神经节苷脂治疗28例重型颅脑损伤患者的疗效分析  

Analysis on the Curative Effect of Ganglioside in 28 Cases of Severe Craniocerebral Injury

作　　者：余健[1] 

机构地区：[1]解放军第425医院,海南三亚572000

出　　处：《北华大学学报（自然科学版）》2012年第5期540-542,共3页Journal of Beihua University（Natural Science）

摘　　要：目的研究证实神经节苷脂在重型颅脑损伤患者的治疗中具有确切的疗效.方法解放军第425医院从2008年1月—2011年1月治疗的186例重型颅脑损伤患者中选取56例作为临床研究对象,对其临床资料进行回顾性分析.将患者随机分为两组,每组病例28例.对照组使用常规治疗;观察组在常规治疗的基础上使用神经节苷脂进行治疗,并对两组研究对象的疗效进行统计学分析.结果观察组在重度脑水肿、呼吸异常、心律失常等发病率均较对照组显著降低,且具有统计学意义(P<0.05);在治疗后10 d患者的GCS分值、神经功能缺失评分及随访2个月的GOS评分等数据的比较中,观察组均较对照组有明显优势,且具有统计学意义(P<0.05).结论神经节苷脂在重型颅脑损伤患者的治疗中能够显著改善患者的脑水肿、颅内压和脑供血,对神经功能的恢复具有显著的促进作用,并具有确切的疗效.Objective To study and confirm the curative effect of ganglioside in patients with severe head injury.Method 56 cases selected from 186 patients with severe craniocerebral injury,hospitalized from January 2008 to January 2011 in Sanya PLA 425 hospital were taken as the objects of clinical study,and the clinical data on them were retrospectively analyzed.The patients were randomly divided into two groups,observation group and control group,and there were 28 cases in each group.The patients in the control group were treated by using conventional therapy,the patients in the observation group were given ganglioside on the basis of the conventional therapy,and curative effects of the therapies on patients in the two groups were statistically analyzed.Results In the observation group,the incidences of severe brain edema,respiratory abnormalities,and arrhythmia were significantly decreased compared with those in the control group,and the differences between two groups were significant(P<0.05);on day 10 after the treatment,patients' GCS scores,scores of neurological impairment and GOS scores obtained from the follow-up for 2 months were significantly better than those in the control group(P<0.05).Conclusion Ganglioside can significantly improve the brain edema,intracranial pressure and cerebral blood supply of patients with severe craniocerebral injury,and promote prominently the recovery of nervous function,it can produce a specific efficacy on severe craniocerebral injury.

关 键 词：神经节苷脂 颅脑损伤 脑水肿 颅内压 疗效 

分 类 号：R651[医药卫生—外科学]