膀胱过度活动症症状评分表评估膀胱过度活动症的临床研究  

The assessment of the overactive bladder symptoms score in clinical practice of overactive bladder symptoms

作　　者：杨尚琪[1] 来永庆[1] 陈月英[1] 池泽湃[1] 任瑞[1] 王亚东[1] 魏灿[1] 倪梁朝[1] 关志忱[1] 

机构地区：[1]北京大学深圳医院泌尿外科,广东省518036

出　　处：《中华临床医师杂志（电子版）》2012年第16期4675-4678,共4页Chinese Journal of Clinicians(Electronic Edition)

基　　金：深圳科学技术项目课题(201002078)

摘　　要：目的确定膀胱过度活动症症状评分表(OABSS)在评价膀胱过度活动症(OAB)中的临床应用价值。方法初发的OAB患者接受抗毒蕈碱药物托特罗定治疗。在基线期及12周治疗后完成3d排尿日记和OABSS,通过对比分析治疗前后相关指标的变化、变量的一致性和变化的相关性。结果本次研究包括59例患者,男22例,女37例,年龄(31.1±9.6)岁,OABSS和相应的3d排尿日记均显示有统计学意义的疗效改善变化。OABSS中尿急评分的效应值最大(2.10),总评分效应值1.55,排尿日记中尿急评分效应值0.92。OABSS中除白天排尿次数外,其余效应值均大于相应排尿日记的效应值,标准反应均数的变化与效应值的变化相同。OABSS中项目评分和相应排尿日记的变量在基线期及12周治疗后有良好的一致性。急迫性尿失禁及夜尿在OABSS和相应排尿日记的变量有高度相关性。结论 OABSS对治疗相关OAB症候群变化有高度敏感性,在日常临床实践中,OABSS借其简易性及可靠性,可成为排尿日记之外的一种可供选择的评估症状和疗效的工具。Objective To determine the Overactive Bladder Symptom Score(OABSS)as a tool for assessing symptoms of overactive bladder(OAB).Methods Treatment-naive OAB patients received an antimuscarinic agent.At baseline and 12 weeks after treatment,patients completed a 3-day bladder diary and the OABSS.Relationships between the 2 methods were evaluated by comparison of changes after treatment,agreement between variables and correlation between changes.Results In total,49 patients[22 males and 37 females,mean age(31.1±9.6)years]were included in the analysis.Statistically significant improvements were noted for all the OABSS and the corresponding diary variables.The effect size(ES)was largest for the OABSS urgency score(2.10),followed by the OABSS total score(1.55),and then by the diary urgency score(0.92).All of the ESs for the OABSS,except daytime frequency,were larger than those of the corresponding diary variables.The standard response means followed a similar pattern to the ESs.A fairly good agreement between OABSS items and the corresponding diary variables was found at baseline and 12 weeks(kappa coefficient,0.33-0.80).High correlations(Spearman′s rho,>0.5)between changes in OABSS items and the corresponding diary variables were found for urgency incontinence and night-time frequency.Conclusions The OABSS is highly sensitive to treatment-related changes of OAB symptoms.Because of its simplicity and dependability,the OABSS can be an alternative to a bladder diary for symptom and efficacy assessment in daily clinical practice.

关 键 词：膀胱 过度活动性 膀胱过度活动症症状评分表 

分 类 号：R694[医药卫生—泌尿科学]