左乙拉西坦的合成研究  

Research on the Synthesis of Levetiracetam

作　　者：吴东山[1] 张元元[1] 李有桂[1] 

机构地区：[1]合肥工业大学化工学院,安徽合肥230009

出　　处：《合肥师范学院学报》2012年第6期68-70,共3页Journal of Hefei Normal University

基　　金：安徽高校省级自然科学研究产学研重点项目资助(No:KJ2010A021)

摘　　要：以4-溴丁酸甲酯与L-2-氨基丁酰胺盐酸盐为原料,在Na2CO3(或K2CO3)的作用下,烷基化、关环得左乙拉西坦。同时考察了影响反应的主要因素,优化了反应条件,反应总收率为59.41%。产物经核磁、红外进行了确证。Levetiracetam was obtained by alkylation,cyclization from methyl 4-bromobutyrate and L-2-Aminobutanamide hydrochloride under the catalysis of Na2CO3(or K2CO3).The main influencing factors were investigated and the reaction conditions were optimized,the total yield was 59.41%.The product was characterized by proton nuclear magnetic resonance spectra(1H NMR) and infrared spectra(IR).

关 键 词：左乙拉西坦 4-溴丁酸甲酯 抗癫痫 合成 

分 类 号：O621.25[理学—有机化学]