3,3-二甲基-4-戊烯酸甲酯合成方法的改进及表征  

Improved Synthesis of 3,3-Dimethyl-4-pentenoic Acid Methyl Ester

作　　者：廖艳芳 余慧群 莫友彬 周海 彭初和 

机构地区：[1]广西化工研究院,广西南宁530001

出　　处：《精细化工中间体》2012年第5期14-16,共3页Fine Chemical Intermediates

基　　金：广西自然科学基金重点项目(2010GXNSFD013020)

摘　　要：采用相模法以原乙酸三甲酯与3-甲基-2-丁烯醇为原料,经过重排反应和酯交换反应,合成了除虫菊酯类杀虫剂的重要中间体3,3-二甲基-4-戊烯酸甲酯。改进相模的工艺更适应工业生产,收率达到85.6%,产品纯度达到99.2%。3,3-Dimethyl-4-pentenoic acid methyl ester is an important intermediate for the synthesis of pyrethroids pesticides.It can be prepared using 3-methyl-2-buten-1-ol and trimethyl orthoacetate as the starting materials,through Claisen rearrangement and transesterification reaction(Sagami method).This method was improved for industrial production and the product was obtained in 85.5% yield with purity of 99.2%.

关 键 词：3 3-二甲基-4-戊烯酸甲酯 3-甲基-2-丁烯醇 原乙酸三甲酯 合成 

分 类 号：TQ453.6[化学工程—农药化工]