噻萘普汀钠的合成  

Synthesis of Tianeptine Sodium

作　　者：张国龙[1] 张珩[1] 杨艺虹[1] 张秀兰[1] 安然[1] 

机构地区：[1]武汉工程大学 绿色化工过程省部共建教育部重点实验室,湖北武汉430073

出　　处：《精细化工中间体》2012年第5期22-24,28,共4页Fine Chemical Intermediates

摘　　要：以三环酮3-氯-6-甲基二苯并[c,f][1,2]硫氮杂-11(6H)-酮-5,5-二氧化物为原料经还原、卤代,与7-氨基庚酸乙酯盐酸盐反应,最后经碱水解制得噻萘普汀钠,总收率32.3%。合成方法成本较低,条件温和,操作简便,具有工业化应用前景。The titled compound was synthesized,via steps of reduction,halogenation,reaction with 7-aminoheptanoic acid ethyl ester hydrochloride and alkaline hydrolysis,using dibenzothiazepin-11(6H)-one-2-chloro-6-methyl-5,5-dioxide as the starting material.The process has the advantages of low costs,mild reaction conditions,simple operation and suitable for industrial production.

关 键 词：抗抑郁 噻奈普汀钠 合成 

分 类 号：R971.43[医药卫生—药品]