AT1R基因A1166C多态性与急性心肌梗死的相关性研究  

Correlation Study between AT1R Gene A1166C Polymorphism and Acute Myocardial Infarction

作　　者：彭建业 张玲 尹凯[2] 桂庆军[2] 

机构地区：[1]南华大学附属第二医院心内科,湖南衡阳421001 [2]南华大学医学院诊断学教研室,湖南衡阳421001

出　　处：《现代诊断与治疗》2012年第12期2059-2062,共4页Modern Diagnosis and Treatment

基　　金：湖南省科技厅科研基金项目资助(2007SK3092)

摘　　要：目的研究AT1R基因A1166C多态性与急性心肌梗死(AMI)的相关性。方法采用PCR-RFLP方法,对105例初发AMI患者和111例健康对照个体进行AT1R基因A1166C多态性分析。结果 AT1R基因A1166C多态性中AA和AC+CC基因型在AMI患者组的频率分别为88.6%和11.4%,等位基因A和C的频率分别为93.3%和6.7%;AA和AC+CC基因型在对照组中的频率分别为92.8%和7.2%,等位基因A和C的频率分别为95.9%和4.1%。AMI组与对照组比较,AA和AC+CC基因型频率及A和C两等位基因频率均无统计学显著性差异(P>0.05)。Logistic回归分析显示高血压、冠状动脉疾病家族史、高密度脂蛋白胆固醇、低密度脂蛋白胆固醇是AMI发生的独立危险因素(P<0.05),高密度脂蛋白胆固醇是保护性因素(OR<1,95%CI 0.155～0.931),其余三项为危险因素(OR>1)。结论 AT1R基因A1166C多态性与AMI的发生可能无关联。Objective To study the relationship between AT1R gene A1166C polymorphism and acute myocardial infarction.Methods 105 patients with newly AMI patients and 111 healthy control subjects were analyzed by AT1R gene A1166C polymorphism.Results The frequency of AA and AC+CC genotype in AT1R gene A1166C polymorphism of AMI patient group were 88.6% and 11.4%,respectively.The frequency of AA and AC + CC genotype in the control group were 92.8% and 7.2%,respectively.The frequency of allele A and C,respectively,were 95.9% and 4.1%.Both AA and AC + CC genotype frequency,A and C allele frequencies were not statistically significant difference between AMI group and control group(P>0.05).Logistic regression analysisshowed that hypertension,family history of coronary artery disease,high density lipoprotein cholesterol,low density lipoprotein cholesterol were the independent risk factors of AMI(P<0.05).High density lipoprotein cholesterol was the protective factor(OR<1,95%CI 0.155～0.931),the remaining three were risk factors(OR>1).Conclusion The AT1R gene A1166C polymorphism may not be associated with the occurrence of AMI.

关 键 词：血管紧张素Ⅱ1型受体(AT1R) 基因多态性 急性心肌梗死 

分 类 号：R542.22[医药卫生—心血管疾病]