曲匹布通合成的改进  

Technological Improvement of Synthesis for Trepibutone

作　　者：陈小全[1] 周秀艳[2] 左之利[3] 张昌军[1] 翟虎[1] 邵辉莹[1] 

机构地区：[1]泰山医学院化学与化学工程学院,泰安271000 [2]四川大学化工学院,成都610065 [3]中国科学院上海药物研究所,上海201203

出　　处：《化工中间体》2012年第9期33-35,共3页

摘　　要：本文探讨合成曲匹布通的新方法、方法,以硝基苯为原料,研究超声功率、时间对合成曲匹布通的影响,所合成目标化合物经过IR,MS,1HNMR谱确证。通过与文献报道路线的对比,在超声波作用下合成曲匹布通反应时间为9.3h、产率为38.4%。此法在合成曲匹布通时,能够使合成时间缩短且产率提高。Objective Exploring new method for synthesis of trepibutone.Method A synthetic method was investigated by the treatment of the nitrobenzene under ultrasonic irradiation.Result The time of the new synthesis method was 9.3 hours and yield was 38.4%.The strcuture of the synthetic compound was identified by IR,MS and 1H NMR.Conclusion This new synthetic route is feasible to the preparation of trepibutone.

关 键 词：硝基苯 合成 曲匹布通 超声波 改进 

分 类 号：TQ463.2[化学工程—制药化工]