高通量技术与网络药理学在中药活性成分筛选中的应用  

Application of network pharmacology and high through-put technology on active compounds screening from traditional Chinese medicine

作　　者：刘庆山[1] 张梓倩[1] 方亮[2] 江一帆[3] 尹小英[3] 

机构地区：[1]中央民族大学中国少数民族传统医学研究院,北京100081 [2]苏州大学,江苏苏州215006 [3]江西中医学院药学院,江西南昌330004

出　　处：《中国中药杂志》2012年第2期134-137,共4页China Journal of Chinese Materia Medica

基　　金：国家自然科学基金面上项目(30973959;20962012;81173657);中央高校基本科研业务费专项基金(0910KYXJ12)

摘　　要：目的:解决中药活性成分筛选的技术瓶颈。方法:根据实验室前期研究结果和相关文献,分析了有关通量研究技术,总结了课题组在网络药理学的指导下利用通量技术筛选中药活性成分。结果:快速制备、高通量筛选、高通量生物芯片技术以及组合药靶网络对于中药活性成分筛选、毒性成分排除、药物分子机制研究均有重要价值,是中药现代化及网络药理学研究的关键技术。结论:高通量技术与网络药理学相结合可提高中药活性成分筛选的效率。Objective:To solve the difficult in the active compounds screening from traditional Chinese medicines(TCM).Method:According to preliminary lab results and related literature,systematic analysis of the high-throughput technology was made.Result:Technologies of rapid preparation,high-throughput screening and biochip,together with the thought of drug target network,will contribute to TCM research on active ingredients screening,toxic components exclusion and molecular mechanisms.They are key technologies and ideas for modernization of TCM and research of TCM network pharmacology.Conclusion:High throughput technology and network pharmacology-related technologies will provide new ideas and key methods for active compounds screening from TCM.

关 键 词：中药 活性成分筛选 网络药理学 高通量技术 生物芯片 

分 类 号：R285[医药卫生—中药学]