延胡索化学成分研究  

Chemical constituents from Corydalis yanhusuo

作　　者：吕子明[1,2] 孙武兴[2] 段绪红 杨志云[2] 刘亚东[2] 屠鹏飞[1] 

机构地区：[1]北京大学药学院天然药物与仿生药物国家重点实验室,北京100191 [2]北京以岭有限公司,北京100027

出　　处：《中国中药杂志》2012年第2期235-237,共3页China Journal of Chinese Materia Medica

基　　金：国家“重大新药创制”科技重大专项(2011ZX09401-120)

摘　　要：目的:对延胡索Corydalis yanhusuo块茎化学成分进行分离和鉴定。方法:应用大孔树脂、硅胶和Sephadex LH-20等色谱技术进行分离纯化,根据理化性质和光谱数据鉴定化合物的结构。结果:分离鉴定了22个化合物,分别为延胡索甲素(1),延胡索乙素(2),原阿片碱(3),四氢紫堇萨明(4),四氢黄连碱(5),四氢小檗碱(6),四氢非洲防己胺(7),降氧化北美黄连次碱(8),脱氢紫堇碱(9),脱氢海罂粟碱(10),非洲防己胺(11),8-氧黄连碱(12),13-甲基非洲防己胺(13),黄连碱(14),巴马亭(15),小檗碱(16),氧海罂粟碱(17),13-甲基巴马亭红碱(18),脱氢紫堇鳞茎碱(19),千金藤宁碱(20),腺苷(21),δ-乙酰鸟氨酸(22)。结论:化合物13,20,21,22为首次从该植物中分离获得。Objective:To investigate the chemical constituents of Corydalis yanhusuo.Method:The compounds were isolated and purified by column chromatography over macroporous absorption resin,silica gel,and Sephadex LH-20.Their structures were elucidated on the basis of physicochemical properties and spectral data.Result:22 compounds were isolated and identified as corydaline(1),tetrahydropalmatine(2),protopine(3),tetrahydrocorysamine(4),tetrahydrocoptisine(5),tetrahydroberberine(6),tetrahydrocolumbamine(7),noroxyhydrastine(8),dehydrocorydaline(9),glaucine(10),columbamine(11),8-oxocoptisine(12),13-methyl-columbamine(13),coptisine(14),palmatine(15),berberine(16),oxoglaucine(17),13-methyl-palmatrubine(18),dehydrocorybulbine(19),stepharanine(20),adenosine(21),and N5-acetylornithine(22).Conclusion:Compounds 13,20,21,and 22 were isolated from this plant for the first time.

关 键 词：延胡索 化学成分 生物碱 

分 类 号：R284[医药卫生—中药学]