白沙蒿化学成分研究  

Study on chemical constituents of Artemisia sphaerocephala

作　　者：张杰[1] 李林玺[1] 刘绣华[1,2] 王勇[1,2] 赵东保[1,2] 

机构地区：[1]河南大学天然药物与免疫工程省重点实验室,河南开封475004 [2]河南大学化学化工学院环境与分析科学研究所,河南开封475004

出　　处：《中国中药杂志》2012年第2期238-242,共5页China Journal of Chinese Materia Medica

基　　金：河南省科技厅科技发展计划项目(092102310282)

摘　　要：目的:研究白沙蒿全草的化学成分。方法:采用硅胶、Sephadex LH-20柱色谱等方法对其化学成分进行分离纯化,通过化合物的理化性质和波谱数据鉴定其结构。结果:从白沙蒿全草中分离鉴定了15个化合物,分别为5-羟基-7,4'-二甲氧基二氢黄酮(1),5-羟基-7,4'-二甲氧基黄酮(2),3,5-二羟基-7,4'-二甲氧基二氢黄酮(3),5,3'-二羟基-7,4'-二甲氧基二氢黄酮(4),5,7-二羟基-6,4'-二甲氧基黄酮(5),异野樱素(6),橙皮素(7),柑桔素(8),金合欢素(9),金圣草黄素(10),5,7-二羟基-4'-甲氧基-6,8-二-C-β-葡萄糖苷(11),香蜂草苷(12),金合欢素-7-O-芸香糖苷(13),云杉苷(14),茵陈素(15)。结论:化合物1～3,5,7～8,10～15均为首次从该植物中分离得到。Further study on the chemical constituents of Artemisia sphaerocephala led to the isolation of fifteen compounds.These compounds were isolated and purified by repeated column chromatography on silica gel and Sephadex LH-20.Their structures were determined by physicochemical properties and spectral data analysis.These compounds were identified as 5-hydroxy-7,4'-dimethoxyflavanone(1),5-hydroxy-7,4'-dimethoxyflavone(2),5-hydroxy-7,4'-dimethoxyflavanonol(3),5,3'-dihydroxy-7,4'-dimethoxyflavanone(4),5,7-dihydroxy-6,4'-dimethoxyflavone(5),isosakuranetin(6),hesperetin(7),navingenin(8),acacetin(9),chrysoeroil(10),5,7-dihydroxy-4'-methoxyflavone-6,8-di-C-glucopyranoside(11),didymin(12),acacetin-7-O-rutinoside(13),piceine(14),and capillarin(15).Compounds 1-3,5,7,8,10-15 were isolated from this plant for the first time.

关 键 词：白沙蒿 菊科 蒿属 化学成分 黄酮 

分 类 号：R284[医药卫生—中药学]