高+Gz暴露对飞行员唾液分泌型免疫球蛋白A和皮质醇浓度的影响  

Effects of high +Gz exposure on saliva sIgA and cortisol levels in pilots

作　　者：李卫东[1] 薛霞[1] 薛红[1] 赵青平[1] 周晓英[1] 

机构地区：[1]空军航空医学研究所载人离心机医学训练基地,北京100089

出　　处：《中华航空航天医学杂志》2013年第2期113-116,共4页Chinese Journal of Aerospace Medicine

摘　　要：目的 探讨高正加速度(+Gz)暴露对飞行员唾液分泌型免疫球蛋白(secretory immu-noglobulin A,sIgA)和皮质醇浓度的影响,以进一步认识+Gz应激反应的特点及机制. 方法 47名高性能战斗机飞行员着抗荷服进行载人离心机训练,分别在+6.5Gz、+7.0Gz和+8.0 Gz暴露前后取其唾液,采用微粒子化学发光法和免疫比浊法检测唾液sIgA和皮质醇浓度. 结果 ①+6.5Gz、+7.0Gz、+8.0Gz暴露后sIgA稍有上升,但与暴露前相比无统计学差异；+6.5 Gz、+7.0Gz、+8.0Gz暴露后唾液皮质醇浓度均高于离心机训练前水平(F=3.427,P＜0.05),其中+8.0Gz暴露后唾液皮质醇浓度较+6.5Gz暴露后、+7.0Gz暴露前、+8.0Gz暴露前均高(P＜0.05).②重复测量多元方差分析的结果显示机种、年龄、飞行总时间3个因素对不同+Gz暴露后飞行员唾液sIgA和皮质醇浓度无影响.③飞行员唾液sIgA浓度与年龄、飞行总时间、飞行机种及+Gz值无相关性；飞行员唾液皮质醇浓度与飞行员年龄、飞行机种呈负相关(r=-0.328、-0.694,P＜0.05),与飞行总时间、+Gz值呈正相关(r=0.466、0.141,P＜0.05). 结论 +Gz暴露对飞行员sIgA浓度无影响；高+Gz暴露可提高飞行员唾液皮质醇浓度,对黏膜免疫功能无影响；唾液皮质醇浓度可作为高+Gz应激反应的监测指标.Objective To investigate the influence of positive (+Gz) acceleration exposure on saliva secretory immunoglobulin A (sIgA) and cortisol concentrations of pilots,so as to completely understand the characterisitics and mechanism of +Gz reaction.Methods Forty-seven high performance pilots trained on human centrifuge with the protection of G-suit.Their saliva was collected before and after + 6.5 Gz,+ 7.0 Gz,+ 8.0 Gz exposures on centrifuge.Saliva sIgA and cortisol concentrations were measured with chemiluminescent immunoassay immunoturbidimetry.Results ①Compared with the data got before exposures,saliva sIgA rose slightly after +6.5 Gz,+7.0 Gz,+ 8.0 Gz exposures.But there was no significant difference among them.Cortisol concentration in saliva collected after +6.5 Gz,+7.0 Gz,+8.0 Gz exposures was significantly higher than that before exposures (P＜0.05).Cortisol concentration after +8.0 Gz exposure was significantly higher than that after +6.5 Gz exposure,before +7.0 Gz exposure and before +8.0 Gz exposure (P＜0.05).②ANOVA analysis showed that aircraft types,age and total flying hours had no influence to saliva sIgA and cortisol concentrations during different exposures.③Pilot's salivary sIgA had no correlation with age,flying hours,aircraft types and the level of +Gz exposure.Salivary cortisol had negative correlation with pilot's age and aircraft types (r=-0.328,-0.694,P＜0.05),but had positive correlation with flying hours and the level of +Gz exposure (r=0.466,0.141,P＜0.05).Conclusions + Gz exposure has no effect on sIgA concentration.High acceleration exposure can lead to high cortisol concentration,but have no effect on mucosal immune functions.Saliva cortisol can be used as an indicator for monitoring high +Gz stress reaction.

关 键 词：加速度 唾液 免疫球蛋白A 分泌 皮质醇 

分 类 号：R852.21[医药卫生—航空、航天与航海医学]