Two-stage Source Reconstruction Algorithm for Bioluminescence Tomography Using Hybrid FEM  

作　　者：Hou, Yan-Bin  Zhao, Heng  Qu, Xiao-Chao  Chen, Duo-Fang  Wang, Xiao-Rui  Liang, Ji-Min 

机构地区：[1] Life Sciences Research Center, School of Life Sciences and Technology, Xidian University, Xi'an 710071, China [2] School of Technical Physics, Xidian University, Xi'an 710071, China

出　　处：《International Journal of Automation and computing》2012年第3期225-231,共7页国际自动化与计算杂志（英文版）

基　　金：supported by National Basic Research Program of China (973 Program) (No. 2011CB707702);National Natural Science Foundation of China (Nos. 81090272, 81000632, and 30900334);the Shaanxi Provincial Natural Science Foundation (No. 2009JQ8018);the Fundamental Research Funds for the Central Universities

摘　　要：A two-stage source reconstruction algorithm for bioluminescence tomography (BLT) is developed using hybrid finite element method (FEM). The proposed algorithm takes full advantages of linear and quadratic FEMs, which can be used to localize and quantify bioluminescent source accurately. In the first stage, a large permissible region is roughly determined and then iteratively evolved to reduce matrix dimension using efficient linear FEM. In the final stage, high-convergence quadratic FEM is applied to improve reconstruction result. Both numerical simulation and physical experiment are performed to evaluate the proposed algorithm. The relevant results demonstrate that quantitative reconstruction can be well achieved in terms of computation efficiency, source position, power density, and total power when compared with previous studies.A two-stage source reconstruction algorithm for bioluminescence tomography (BLT) is developed using hybrid finite element method (FEM). The proposed algorithm takes full advantages of linear and quadratic FEMs, which can be used to localize and quantify bioluminescent source accurately. In the first stage, a large permissible region is roughly determined and then iteratively evolved to reduce matrix dimension using efficient linear FEM. In the final stage, high-convergence quadratic FEM is applied to improve reconstruction result. Both numerical simulation and physical experiment are performed to evaluate the proposed algorithm. The relevant results demonstrate that quantitative reconstruction can be well achieved in terms of computation efficiency, source position, power density, and total power when compared with previous studies.

关 键 词：Molecular imaging bioluminescence tomography source reconstruction TWO-STAGE finite element method (FEM). 

分 类 号：TN911.74[电子电信—通信与信息系统]