胚胎干细胞向成骨细胞定向分化的研究进展  

Research Development of the Directed Differentiation of Embryonic Stem Cells into Osteoblasts

作　　者：曹澍[1] 凡生[1] 张林波[1] 

机构地区：[1]解放军第208医院放射科,吉林长春130000

出　　处：《黑龙江医学》2013年第1期73-76,共4页Heilongjiang Medical Journal

摘　　要：目的对胚胎干细胞(embryonic stem cells,ESCs)体外诱导定向分化为成骨细胞的研究现状及所存在的问题作一综述。方法广泛查阅近年来关于ESCs体外诱导分化为成骨细胞的文献,并进行总结和分析。结果 ESCs可以作为理想的骨组织工程种子细胞来源。结论体外诱导ESCs定向分化得到成骨细胞,在骨组织工程中具有巨大的潜力,不但提供了分析成骨细胞发生的分子机制模型,也奠定了其在骨组织修复中的基础。Objective To summarize the present situation and the questions about how embryonic stem cells become osteoblasts through vitro induction directed differentiation.Methods Reviewing,summarizing and analyzing literature on how embryonic stem cells become osteoblasts through vitro induction in recent years.Results ESCs can be used as the ideal resource of bone tissue engineering seeds.Conclusion The osteoblasts gotten from vitro induction directed differentiation have great potential in bone tissue engineering,they not only provide the molecular mechanisms model for analyzing how to get osteoblasts but also lay the foundation for them in bone tissue repair.

关 键 词：胚胎干细胞 成骨细胞 定向分化 

分 类 号：R329.2[医药卫生—人体解剖和组织胚胎学]