C-反应蛋白与急性心肌梗死后左心室重塑关系的临床研究  

Study on the CRP Concentrations in Left Ventricular Remodeling after AMI

作　　者：沈桂彬[1] 

机构地区：[1]郑州市第七人民医院急诊科,河南郑州450016

出　　处：《黑龙江医学》2013年第5期324-326,共3页Heilongjiang Medical Journal

摘　　要：目的探讨血浆C-反应蛋白(CRP)浓度在急性心肌梗死(AMI)后左心室重塑中的临床意义。方法测定首次AMI患者发病后血浆CRP的浓度,并进行超声心动图检查,测定左心室舒张末期内径(LVEDD)和左心室射血分数(LVEF),根据计算出的左心室舒张末期容积指数增加率(△LVEDVI)将患者分为左心室重塑组和无左心室重塑组。结果 AMI后左心室重塑组血浆CRP的峰值水平为(122±43)mg/L,高于无左心室重塑组的(68±32)mg/L,差异有统计学意义(P<0.05);左心室重塑组血浆CRP的峰值水平与△LVEDVI呈正相关(P<0.01),与LVEF呈负相关(P<0.01),且其相关性高于无左心室重塑组。结论 CRP水平可作为评价AMI后左心室重塑的一种简单易行的指标。Objective To investigate the clinical significance of the plasma concentration of C-reactive protein(CRP) in left ventricular remodeling(LVR) after Acute Myocardial Infarction(AMI).Methods The levels of plasma CRP concentration were determined in patients after AMI.Left ventricular end diastolic diameter and left ventricular ejection fraction(LVEF) were measured by echocardiography.The patients were divided into two groups according to the levels of △LVEDVI,i.e.LVR group and non-LVR group.Results The peak concentration of CRP in LVR group was higher than that of non-LVR group(122±43 VS 68±32)mg/L(P<0.05).There was significant positive correlation between the levels of CRP and △LVEDVI in LVR group(P<0.01).There was a significant negative correlation between the levels of CRP and LVEF in LVR group(P<0.01).Conclusion The CRP levels can be used as an index in evaluating left ventricular remodeling and heart function after AMI.

关 键 词：C-反应蛋白 急性心肌梗死 左心室重塑 

分 类 号：R542.22[医药卫生—心血管疾病]