GC-MS法同时测定塑料类药包材中16种邻苯二甲酸酯类增塑剂  

Simultaneous determination of 16 phthalic acid esters in plastic drug packages by GC-MS

作　　者：吉琅[1] 廖晴[1] 吴恋[1] 吕维[1] 杨茗[1] 范成杰[1] 万丽[1] 

机构地区：[1]成都中医药大学药学院 中药材标准化教育部重点实验室 中药资源系统研究与开发利用省部共建国家重点实验室培育基地,四川成都610075

出　　处：《中药与临床》2013年第2期35-38,41,共5页Pharmacy and Clinics of Chinese Materia Medica

摘　　要：目的:建立塑料类药包材中16种邻苯二甲酸酯类增塑剂的定性、定量分析方法。方法:采用气相色谱质谱联用法,色谱柱:弹性石英毛细管柱(30m×0.32mm×0.25μm)HP-5MS;载气:高纯氦气;离子源温度:230℃;GC-MS辅助加热温度:250℃;四级杆温度:150℃;采用分段选择离子监测(SIM)模式。结果:本方法的检测限和定量限分别为0.003～0.050μg.g-1,0.005～0.145μg.g-1。各种增塑剂在一定的浓度范围内呈线性,相关系数大于0.9965,回收率在86.404%～101.212%之间(RSD均小于5.600%,n=9),重复性(RSD,n=9)小于6.175%,精密度(RSD,n=9)小于6.958%。结论:本研究建立的药包材中16种邻苯二甲酸酯类增塑剂残留检测的GC-MS方法简单、灵敏,定性、定量准确并且具有良好的重现性和精密度,可满足药包材中多种增塑剂的定性、定量测定要求,具有实际的应用价值。Objective:To establish a method for qualitatively and quantitatively detecting 16 phthalic acid esters in plastic drug packaging by GC-MS.Method:Gas chromatography mass spectrometry was applied.The column was fused silica capillary column(30 m × 0.32 mm × 0.25 μm) with Helium as carrier gas.Ion source temperature was set at 230 ℃,and auxiliary heating temperature was set at 250 ℃,and quadrupole temperature was set at 150 ℃.Truncate selection ion monitoring(SIM) mode was selected.Result:The limits of detection and the limits of quantitation for the assay ranged from 0.003-0.050 μg·g-1and 0.005-0.145 μg·g-1,respectively.The calibration curves were all linear with a correlation coefficient r > 0.9965.Recoveries ranged from 86.404% to 101.212%(RSD < 5.600%,n = 9),reproducibility(RSD,n = 9) was less than 6.958%,precision(RSD,n = 9) was less than 6.175%.Conclusion:The method is simple,sensitive and accuracy with good recovery and precision.It can satisfy the qualitative and quantitative requirement in the detecting various plasticizer,and has application values.

关 键 词：邻苯二甲酸酯类增塑剂 GC-MS 药包材 定性定量 

分 类 号：R917[医药卫生—药物分析学]