负载水杨酸的N-十六酰-L-组氨酸水凝胶药物缓释研究  

Study on Drug Release of N-Palmitoyl-L-histidine Hydrogel Loaded with Salicylic Acid

作　　者：樊凤连 陈颖飞 王科军[1] 罗序中 梅光泉[2] 

机构地区：[1]赣南师范学院化学化工学院,赣州341000 [2]宜春学院化学与生物工程学院,宜春336000

出　　处：《精细石油化工进展》2013年第1期55-58,共4页Advances in Fine Petrochemicals

基　　金：江西省教育厅科学技术研究项目(GJJ10234);江西省自然科学基金(20111522040195;2010GZH0018);江西省高校应用化学与化学生物学重点验室项目(GJJ11707)

摘　　要：用合成的N-十六酰-L-组氨酸与用乙醇-水(V乙醇∶V水=1∶1)混合溶剂溶解的水杨酸制成水凝胶,通过X射线衍射和药物缓释实验研究了该水凝胶的性能。结果表明,制得的水凝胶是一种很好的药物载体,且在pH=7时凝胶的稳定性最好。在pH=7.41的缓冲溶液中,水杨酸呈现较好的缓释效果;在偏碱性(pH=10.00)的缓冲溶液中,药物缓释过快,且凝胶不稳定,易松散溶解;在偏酸性(pH=4.04)的缓冲溶液中,释放率稍偏低。低浓度(5 mg/mL)的N-十六酰-L-组氨酸水凝胶和适宜的温度(37℃)有利于水杨酸的释放。A hydrogel was prepared using synthesized N-palmitoyl-L-histidine and salicylic acid dissolved in mixed solvent of ethanol/water with volume ratio of 1:1.The performances of the hydrogel were investigated by X-ray diffraction(XRD) and the experiments of drug release.The results showed that the hydrogel was an excellent drug carrier and had the best stability at pH=7.The effects of sustained release of salicylic acid were better in the buffer solution with pH=7.41.The drug release was rapid and the hydrogel was instable and easy to loosen and dissolve in the buffer solution with pH=10.00.The rate of drug release was lower in the buffer solution wiht pH=4.04.Salicylic acid was released effectively at 37 ℃ with the low concentration(5 mg/mL) of N-palmitoyl-L-histidine in hydrogel.

关 键 词：水凝胶 组氨酸 药物缓释 水杨酸 

分 类 号：TQ460.1[化学工程—制药化工]