A New Flavone C-glycoside from Citrullus colocynthis  

作　　者：Jing MIAO Jie ZHANG Shi-ming DENG Bin DAI 

机构地区：Key Laboratory for Green Processing of Chemical Engineering of Xinjiang Bingtuan, School of Chemistry and Chemical Engineering, Shihezi University, Shihezi 832003, China[1] Key Laboratory of Tropic Biological Resources of Hainan University, Haikou 570228, China[2]

出　　处：《Chinese Herbal Medicines》2012年第1期1-3,共3页中草药（英文版）

摘　　要：Objective To study the chemical constituents of Citrullus colocynthis. Methods The chemical constituents were isolated and purified by column chromatography on silica gel and Sephadex LH-20 and recrystallization as well. NMR spectra and physicochemical property were characterized for structural identification. Results Eleven compounds were isolated and identified as β-sitosterol (1), α-spinasterol-3-O-β-D-glucopyranoside (2), α-spinasterone (3), bis (2-ethylhexyl) phthalate (4), p-hydroxybenzoic acid (5), 6-C-p-methylbenzoylvitexin (6), dihydrocucurbitacin E (7), cucurbitacin E (8), dihydro-epi-iso-cucurbitacin D (9), dihydroisocucurbitacin B-25-acaetate (10), and cucurbitacin E 2-O-β-D-glucopyranoside (11). Conclusion Compound 6 is a novel compound. Compounds 1-5, 7, 9, and 10 are isolated from C. colocynthis for the first time.Objective To study the chemical constituents of Citrullus colocynthis. Methods The chemical constituents were isolated and purified by column chromatography on silica gel and Sephadex LH-20 and recrystallization as well. NMR spectra and physicochemical property were characterized for structural identification. Results Eleven compounds were isolated and identified as β-sitosterol (1), α-spinasterol-3-O-β-D-glucopyranoside (2), α-spinasterone (3), bis (2-ethylhexyl) phthalate (4), p-hydroxybenzoic acid (5), 6-C-p-methylbenzoylvitexin (6), dihydrocucurbitacin E (7), cucurbitacin E (8), dihydro-epi-iso-cucurbitacin D (9), dihydroisocucurbitacin B-25-acaetate (10), and cucurbitacin E 2-O-β-D-glucopyranoside (11). Conclusion Compound 6 is a novel compound. Compounds 1-5, 7, 9, and 10 are isolated from C. colocynthis for the first time.

关 键 词：CITRULLUS Citrullus colocynthis 6-C-p-methylbenzoylvitexin CUCURBITACIN steride 

分 类 号：R243[医药卫生—中医临床基础]