Visualization of Multivariate Metabolomic Data  

作　　者：AA Ji-ye 

机构地区：[1]Laboratory of Metabolomics,Key Laboratory of Drug Metabolism and Pharmacokinetics,China Pharmaceutical University

出　　处：《Chinese Herbal Medicines》2011年第4期285-289,共5页中草药（英文版）

基　　金：the National Key New Drug Creation Special Programs(2009ZX09304-001 and 2009ZX09502-004);National Natural Science Foundation of the People’s Republic of China(81072692);National Key Fundamental Research"973"Projects(2011CB505300 and 2011CB505303)

摘　　要：Objective Although principal components analysis profiles greatly facilitate the visualization and interpretation of the multivariate data,the quantitative concepts in both scores plot and loading plot are rather obscure.This article introduced three profiles that assisted the better understanding of metabolomic data.Methods The discriminatory profile,heat map, and statistic profile were developed to visualize the multivariate data obtained from high-throughput GC-TOF-MS analysis. Results The discriminatory profile and heat map obviously showed the discriminatory metabolites between the two groups,while the statistic profile showed the potential markers of statistic significance.Conclusion The three types of profiles greatly facilitate our understanding of the metabolomic data and the identification of the potential markers.Objective Although principal components analysis profiles greatly facilitate the visualization and interpretation of the multivariate data,the quantitative concepts in both scores plot and loading plot are rather obscure.This article introduced three profiles that assisted the better understanding of metabolomic data.Methods The discriminatory profile,heat map, and statistic profile were developed to visualize the multivariate data obtained from high-throughput GC-TOF-MS analysis. Results The discriminatory profile and heat map obviously showed the discriminatory metabolites between the two groups,while the statistic profile showed the potential markers of statistic significance.Conclusion The three types of profiles greatly facilitate our understanding of the metabolomic data and the identification of the potential markers.

关 键 词：discriminatory profile heat map metabolomic data principal components analysis statistic profile 

分 类 号：R284.1[医药卫生—中药学] TP391.41[医药卫生—中医学]