二氧化硅负载硅钨钼酸催化合成乙酰水杨酸  

Synthesis of Acetylsalicylic Acid using H_4 SiW_6 Mo_6 O_(40) /SiO_2 as Catalyst

作　　者：杨水金[1] 王荣[1] 程银芳[1] 

机构地区：[1]湖北师范学院化学化工学院,黄石435002

出　　处：《化工中间体》2013年第8期16-19,共4页

摘　　要：以水杨酸和乙酸酐为原料,以二氧化硅负载硅钨钼酸H4SiW6Mo6O40/SiO2为催化剂。探讨H4SiW6Mo6O40/SiO2对合成反应的催化活性,系统地研究了水杨酸和乙酸酐的物质的量比、催化剂用量、反应时间等因素对产物收率的影响。实验表明:H4SiW6Mo6O40/SiO2是合成乙酰水杨酸的良好催化剂,固定水杨酸用量为0.015 mol,在n(水杨酸)∶n(乙酸酐)=1∶2.0,催化剂用量为0.3g,反应时间15min的最佳条件下,乙酰水杨酸的收率可达75.1%。Acetylsalicylic acid was synthesized from salicylic acid and acetic anhydride in the presence of H4 SiW6 Mo6 O4 0/ SiO2 The factors influencing the synthesis were discussed and the best reaction conditions were found out. Experimental results showed that H4 SiW6 Mo6 O4 0/SiO2 is an excellent catalyst. The optimal conditions are: molar ratio of salicylic acid to acetic anhydride is 1:2.0, catalyst dosage is 0.3g(acetylsalicylic acid 0.015 mol) and the reaction time is 15 min, the yield of acetylsalicylic acid can reach 75.1 %.

关 键 词：乙酰水杨酸 H4SiW6Mo6O40/SiO2 催化 

分 类 号：TQ245.12[化学工程—有机化工]