胰岛素抵抗对良性前列腺增生的影响  

Influence of insulin resistance on benign prostate hyperplasia

作　　者：左曼军[1] 魏鸿[1] 缪小玉[1] 袁音[1] 

机构地区：[1]福建省立医院干二科,福建省福州市350001

出　　处：《实用老年医学》2013年第11期952-954,共3页Practical Geriatrics

摘　　要：目的探讨胰岛素抵抗和良性前列腺增生(BPH)的关系。方法以2011年3月至2012年3月在福建省立医院老年科门诊及住院的老年男性BPH病人78例为观察对象,测空腹血糖(FPG)、空腹胰岛素(FINS),运用HOMA模型计算胰岛素抵抗指数(HOMA-IR),以HOMA-IR≥2.8为胰岛素抵抗,分组为胰岛素抵抗组和胰岛素敏感组,观察2组的前列腺体积(PV),前列腺症状评分(IPSS)及血清前列腺特异性抗原(PSA),同时根据FINS及FPG水平分组对前列腺这三项指标进行评估研究。结果胰岛素抵抗组、FINS升高组及FPG升高组均能观察到更为明显增大的PV(P<0.01或0.05),胰岛素抵抗组的IPSS高于胰岛素敏感组(P<0.05)。结论胰岛素抵抗及高胰岛素血症的BPH患者具有更大的前列腺体积和更多临床症状,胰岛素抵抗可能是导致BPH的病因之一。Objective To investigate the association of insulin resistance with benign prostate hyperplasia( BPH). Methods In the period between March 2011 to March 2012,a total of 78 elderly male patients with BPH from outpatient and inpatient departments of geriatric medicine in Fujian provincial hospital were included in this study. Fasting plasma glucose( FPG) and fasting insulin( FINS) levels were measured. Insulin resistance index( HOMA-IR) was calculated using the HOMA model,and insulin resistance was defined as HOMA-IR≥2. 8. Subjects were divided into insulin resistance group and insulin sensitive group. Prostate volume( PV),prostate symptom score( IPSS),and serum prostate specific antigen( PSA) were evaluated in groups according to levels of FPG and FINS. Results Significantly increased prostate volume were observed in insulin resistance group( P < 0. 01),high FPG group( P < 0. 01),and high FINS group( P <0. 05). The level of IPSS in insulin resistance group were higher than that in insulin sensitive group( P < 0. 05). Conclusions The patients with BPH presenting with insulin resistance and hyperinsulinemia show enlarged prostate volume and more relevant symptoms. Insulin resistance could be one of the causes of BPH.

关 键 词：胰岛素抵抗 高胰岛素血症 良性前列腺增生 

分 类 号：R697.32[医药卫生—泌尿科学]