逍遥散及其功效拆方对应激抑郁模型小鼠的影响  

Effects of the decoction of Xiaoyaosan and its efficacy disassembled prescription on stress-induced depression model mice

作　　者：杨靖[1] 龚锡平[1] 刘蓉[1] 王哲[1] 武志强[1] 于柳[1] 史玉荣[1] 曾南[1] 

机构地区：[1]成都中医药大学药学院 中药材标准化教育部重点实验室 中药资源系统研究与开发利用省部共建国家重点实验室培育基地,四川成都611137

出　　处：《中药与临床》2013年第5期26-29,共4页Pharmacy and Clinics of Chinese Materia Medica

基　　金：四川省教育厅自然科学重点项目(09ZA027;13ZA028)

摘　　要：目的:观察逍遥散及其功效拆方对应激抑郁模型小鼠的影响,初步探讨该方抗抑郁效应的功效药组。方法:逍遥散及其功效拆方,即疏肝药组(柴胡、薄荷)、养血药组(当归、白芍)、健脾药组(白术、茯苓、生姜、炙甘草)、疏肝药+健脾药组(柴胡、薄荷、白术、茯苓、生姜、炙甘草)、养血药+健脾药组(当归、白芍、白术、茯苓、生姜、炙甘草)连续灌胃给药7 d,采用小鼠悬尾试验和小鼠强迫游泳试验观察受试药物对模型动物不动时间的影响。结果:逍遥散、疏肝药、养血药、疏肝药+健脾药、养血药+健脾药组均能显著缩短小鼠悬尾试验及强迫游泳试验中的不动时间,且不影响小鼠自主活动;健脾药组作用不明显。结论:逍遥散具有抗抑郁作用,方中体现疏肝治法的柴胡-薄荷药组和体现养血治法的当归-白芍药组是全方发挥作用的重要功效药组。Objective: To observe the effects of the decoction of Xiaoyaosan(XYS) and its efficacy disassembled prescription on stress-induced depression mouse model, so as to reveal the efficacy components of XYS for the antidepressive effect. Method: The antidepressant effects of the decoction of XYS and its efficacy components including SG group(Caihu and Bohe), YX group(Danggui and Baishao), JP group(Baizhu, Fuling, Shengjiang and Zhigancao), SG+JP group(Caihu, Bohe,Baizhu, Fuling, Shengjiang and Zhigancao) and YX+JP group(Danggui, Baishao Baizhu, Fuling, Shengjiang and Zhigancao) were observed using tail suspension test(TST) and forced swimming test(FST) in mice. All groups were treated for 7d by intragastric administration. Result: Compared with the control group, all the testing drugs except JP group significantly reduced the immobility time of mice in TST and FST, but showed no influence on the locomotor activities with the same dose. Conclusion: The decoction of XYS shows antidepressive effect. The SG component and the YX component play important roles in antidepressant effect of Xiaoyaosan recipe.

关 键 词：逍遥散 功效拆方 抗抑郁 悬尾实验 强迫游泳实验 

分 类 号：R285.5[医药卫生—中药学]