术前负荷剂量国产氯吡格雷在急性ST段抬高型心肌梗死介入治疗中的疗效观察  

The effect observation of preoperative loading dose of domestic clopidogrel in PCI of acute ST-segment elevation myocardial infarction interventional

作　　者：贺铿[1] 石刚[1] 赵勇[1] 叶君明[1] 

机构地区：[1]萍乡市人民医院心内科,萍乡337055

出　　处：《中国医学前沿杂志（电子版）》2013年第10期65-67,共3页Chinese Journal of the Frontiers of Medical Science(Electronic Version)

摘　　要：目的比较国产氯吡格雷与进口氯吡格雷在急性ST段抬高型心肌梗死介入治疗中的疗效及安全性。方法 120例急性ST段抬高型心肌梗死患者,随机分为两组,国产氯吡格雷组:58例;进口氯吡格雷组:62例。均在经皮冠状动脉介入治疗(PCI)术前口服负荷剂量600 mg/次、术后75 mg/d。分别观察两组PCI基本特征,9个月的主要临床心血管事件及出血事件、药物不良反应的发生情况。结果国产氯吡格雷组在心血管事件与出血、药物不良反应与进口氯吡格雷组差异无显著性(P>0.05)。结论国产氯吡格雷与进口氯吡格雷在急性ST段抬高型心肌梗死PCI治疗同样安全、有效,但国产氯吡格雷经济效益较进口氯吡格雷高,更适合在我国广泛应用。Objective To compare the therapeutic effects and safety of domestic clopidogrel and import clopidogrel on PCI in acute ST-segment elevation myocardial infarction(STEMI) patients. Methods 120 patients with acute STEMI were randomly divided into domestic clopidogrel group(58 cases) and imported clopidogrel group(62 cases). Before PCI the two groups were respectively given loading dose of domestic or import clopidogrel 600mg;after PCI they were respectively given 75mg every day for nine months. Major clinical cardiovascular events, bleeding events and adverse reaction were observed in the two groups. Results There were no signiifcant difference in cardiovascular events (P>0.05), adverse reaction (P>0.05), bleeding events (P>0.05) between domestic clopidogrel group and import clopidogrel group. Conclusion Domestic clopidogrel is as safe and effective as import clopidogrel in PCI of acute STEMI. Domestic clopidogrel was more beneift for patients than import clopidogrel in price, so domestic clopidogrel was more suitable for wide application in China.

关 键 词：心肌梗死 氯吡格雷 经皮冠状动脉介入治疗 

分 类 号：R542.22[医药卫生—心血管疾病]