全麻药物作用机制的新解——蛋白质翻译后修饰  

New opinion on the mechanisms of general anesthesia:post-translational modification of proteins

作　　者：陆菡[1] 于布为[1] 

机构地区：[1]上海交通大学医学院附属瑞金医院麻醉科

出　　处：《中国继续医学教育》2010年第4期1-7,145,共7页China Continuing Medical Education

摘　　要：从细胞内功能蛋白翻译后修饰的机制探讨全麻原理,是继脂质学说和蛋白质学说后,全麻机制研究领域的最新进展。作者从细胞内蛋白功能的快速调节——磷酸化、泛素化和类泛素化修饰,结合自身的最新研究成果,介绍了全麻药物作用的新机制。Studying the post-translational modification of intracellular functional proteins is the newest progresses in the fleld of general anesthesia mechanisms research. In this review, the authors indicate that three rapid intracellular protein modifications as phosphorylation, ubiquitination, and sumoylation, are participated in the mechanisms of general anesthesia, and show their experimental results about the effects of ubiquitination and sumoylation modifications on the mechanisms of general anesthetics.

关 键 词：全麻机制 泛素化 类泛素 蛋白质修饰 

分 类 号：R9[医药卫生—药学]