鼻硬腫(鼻硬結病)及其在青島所見47例分析的初步報告  

RHINO-SCLEROMA, -ANALYSIS OF 47 CASES SEEN IN TSINGTAO

作　　者：杨名立 赵玉田[1] 

机构地区：[1]山东大学病理教研組

出　　处：《山东大学学报（哲学社会科学版）》1955年第1期106-121,共16页Journal of Shandong University(Philosophy and Social Sciences)

摘　　要：鼻硬腫(Rhinoscleroma)亦稱鼻硬結病,按拉丁原文含有硬而腫的意義,故「鼻硬腫」譯名似更較恰當,在蘇聯文献則簡稱為硬勝病?静崬楹粑赖囊环N慢性炎症性肉芽腫性疾病。病原爲Frisch(1882年)桿菌,據蘇聯文獻則稱爲桿菌,證明該菌實已由氏同時發見。病變多開始在鼻腔前部粘膜,其後外展可累及鼻孔附近皮膚及上唇(故有皮膚硬腫病Scleroma derma之稱):甚或侵犯下唇;內延可達上頜竇、軟,硬顎,鼻咽部、喉、以及懸雍垂、扁桃體、舌、齒齦、鼻淚管、淚囊、咽鼓管、中耳:或侵及外耳道;甚可侵犯氣管及枝氣管,故有「呼吸道硬腫病」(Scleroma respiratorium)之稱。1923年國際耳鼻咽喉科學會正式命名本病爲「硬腫病」。Rhino-scleroma cases are rarely met with, and only a few has been reported in China, so far. In this paper. 47 cases-the largest series in China-confirmed by the pathological dia- gnosis in the recent four years, were analyzed and a detailed discussion, especially about the pathogenesis and mechanism of the development of this disease was made. Chinese and foreign, especially Soviet literatures were reviewed. A great majority of the 47 cases occurred in yonng and middle-aged patients. No definite familial infection had been noticed. In all of the 47 cases, the patients were the natives of Chiao-tung peninsula. It seems that the enviromental influences of the sea may play a part in the development of the malady, but the conclusion could not be made until other parts of China with the same or nearly the same envirement as in Chiao-tung were studied. The clinical course of the disease is long. The prominent clinical symptoms are nasal ob- struction and swelling and hardness of the diseased area; occasionally they may be mis-diag- nosed as syphilis or tuberculosis. In the later stages of the disease, deformity, stricture and very rarely, malignant changes may be resulted. The authors agree with the view-point expressd in the Soviet literature and consider this disease as a systemic metabolic disturbances, though the lesions usually occurred as local ones. Three stages of histelogical changes were differentiated. It was in the second stage that a kind of piculiar cells-the Mikulicz cells were usually found making the diagnosis easy. The lesion were commonly situated in the nose, pharynx, and nasopharynx, etc.. In this paper, the authors also discuss the different therapeutic methods, namely, tissue therapy, streptomycin, irradiation and the combined therapy of streptomycin and irradiation, as well as their therapeutic effects, both clinically and pathologically. The mechanism of the in- duction of streptomycin or irradiation were observed not only to inhibit the growth of the bac- teria, but also to stimulate the

关 键 词：炎症性 上唇 粘膜 下唇 呼吸道 耳鼻咽喉科 唇部 咽鼓管 鼻咽部 病理切片 

分 类 号：C55[社会学]