青蒿琥酯活性代谢产物双氢青蒿素的牛体代谢动力学  

Pharmacokinetics of dihydroartemisnine of the active metabolite of artesunate in cows and cattle

作　　者：薛明[1] 夏文江[1] 霍继曾[1] 周宗田[1] 

机构地区：[1]中国农业科学院兰州畜牧与兽药研究所

出　　处：《中国兽药杂志》2004年第7期1-3,共3页Chinese Journal of Veterinary Drug

基　　金：国家自然科学基金项目 ( 3 870 469)

摘　　要：健康奶牛与黄牛各 5头 ,分别单剂量静注 5mg/kg和 10mg/kg青蒿琥酯 ,用TLC法测定青蒿琥酯的活性代谢产物双氢青蒿素在牛血中的浓度。经统计矩方法计算分析双氢青蒿素的主要药动学参数 。Dihydroartemisinine(DHA) is the active metabolite of artesunate(AS), which is effective in the (treatment) of theileriosis, babesiosis and cocoidiosis in veterinary practice. Artesunate was administered intra-(venously) at the doses of 5 and 10 mg per kg body weight for 5 cows and 5 cattle,respectively. The concentration of DHA in plasma was determined by TLC method developed in our laboratory. The pharmacokinetic parameters of DHA in cows and cattle were analyzed by statistical moment method and compared with the pharmacokinetic (parameters) of AS.

关 键 词：青蒿琥酯 活性代谢产物 双氢青蒿素 牛 代谢动力学 

分 类 号：S858.23[农业科学—临床兽医学] S859.79[农业科学—兽医学]