血小板活化在不稳定型心绞痛(UA)中的临床意义  

The Chilical Significance of Activation Platelet in the Pathogenesis and Progression of Unstable Anginia

作　　者：李晓玲[1] 王庸晋[1] 公慧萍[1] 

机构地区：[1]长治医学院附属和平医院心内科,046000

出　　处：《长治医学院学报》2004年第1期17-19,共3页Journal of Changzhi Medical College

摘　　要：目的 :探讨血小板活化在UA中的临床意义。方法 :采用国内第一株抗人活化血小板α -颗粒膜蛋白 (GMP - 1 4 0 )单克隆抗体SZ - 5 1测定UA患者血小板膜表面GMP - 1 4 0的变化 ,同时观察血浆TXB2 和 6-K -PGF1α的改变。结果 :UA在心绞痛发作时 ,GMP - 1 4 0、TXB2 、6-K -PGF1α均明显高于稳定型心绞痛 (SA)患者和对照组 ,后二者无明显差异。心绞痛终止后 ,升高的GMP - 1 4 0全部恢复正常水平。结论 :UA患者体内血小板明显激活。心绞痛发作时可根据GMP - 1 4 0是否增高以及增高程度来鉴别SA和UA ,并判断预后。Oblective:In order to investigate the clinical significance of platelet activation in the pathogenesis and progression of the unstable angina (UA).Methods: The dynamic changes of platelet function including alpha-granule membrane protein (GMP-140) on the surface of platelet, plasma TXB 2 and 6-K-PGF1α were studied in UA patients.Results:The level of GMP-140 on the platelet surface in UA patients was significantly higher than that in SA when angina episoded.Conclusion:The result indicates that the platelet is highly activated in the patients with UA.The degree of platelet activation correlates with the severity of the disease. The determination of GMP-140 molecules on the surface of platelet not only to diagnose UA and SA,but also to assess the prognosis of the disease

关 键 词：不稳定型心绞痛 血小板 Α-颗粒膜蛋白 血栓烷B2 6-酮-前列腺素F1Α 

分 类 号：R541.4[医药卫生—心血管疾病]