黄连结肠定位释药微丸的制备工艺研究  

Preparation of colon-specific delivery pellets of Huanglian

作　　者：吴珊[1] 李小芳[1] 李航[1] 舒予[1] 罗佳[1] 文怡静[1] 刘玲[1] 

机构地区：[1]成都中医药大学药学院中药材标准化教育部重点实验室中药资源系统研究与开发利用省部共建国家重点实验室培育基地,四川成都611137

出　　处：《中药与临床》2013年第6期14-17,共4页Pharmacy and Clinics of Chinese Materia Medica

基　　金：四川省教育厅重点项目(编号:12ZA042)

摘　　要：目的:将黄连提取物制备成结肠定位释药微丸。方法:采用流化床底喷工艺,根据浸膏性质选择适宜辅料配比,以微丸的载药量为考察指标,研究制备工艺;采用多层包衣法,以黄连总碱体外释放度等为考察指标,对包衣处方中成膜剂种类及比例、增塑剂种类及用量、包衣增重进行筛选。结果:黄连微丸的制备工艺为:称取一定量的黄连浸膏,用50%乙醇溶解,加入10%的微粉硅胶作为抗黏剂,使微丸增重30%;包衣工艺为:先包pH敏感层,包衣增重20%,再包酶触发层,包衣增重10%,即得。结论:体外溶出度试验结果表明,该制剂较好的达到了多元释药目的。Objective: To prepare colon-specific delivery pellets of Huanglian extract. Method: The technology of fluidized bed with bottom-spraying was adopted to prepare the pellets. The excipients proportion was optimized according to the nature of extract. With the drug loading capacity of pellet as index, the preparation technology of colon controlled release pellets of Huanglian was studied. Multiple coating method was adopted to screen the variety and proportion of film-forming agent, the variety and dosage of plastifier, and the increasing of coating thickness in coating prescription with the release rate of total coptis alkaloids in vitro as index. Result: The preparation technology of pellets of Huanglian was as following: weighing a certain amount of the extract of Huanglian and dissolving it with 50% ethyl alcohol with 10% Gum Acacia as anti-adhesive, coating thickness to increase 30% weigh of pellet. Technology of coating was as following: firstly coating with pH sensitivity materials to increase 20% weigh of pellet, and then coating with enzyme-controlled type materials to increase 10% weigh of pellet. Conclusion: The dissolution test shows that this preparation can show the expected effects of colon-specific delivery.

关 键 词：黄连 结肠靶向 微丸 pH敏感型 酶触发型 

分 类 号：R283[医药卫生—中药学]