不同低氧暴露方式高原习服效果比较  

Comparison on the effects of different hypoxic exposures for the acclimatization in plateau

作　　者：吴锋[1] 俞梦孙[1] 曹征涛[1] 杨军[1] 王彬华[1] 罗永昌[1] 

机构地区：[1]空军航空医学研究所,北京100142

出　　处：《中华航空航天医学杂志》2013年第4期252-255,共4页Chinese Journal of Aerospace Medicine

基　　金：全军后勤科技“十二五”重大项目(AKJ11J005)

摘　　要：目的 比较急进高原前渐进式间歇性低氧预习服训练、急进高原后渐进式低氧暴露及急进高原3种不同进驻高原方式的习服效果. 方法 12名青年男性受试者,分为预习服组、供氧组和对照组3组,每组4人.预习服组进驻高原前在常压低氧舱进行连续10 d的渐进式间歇性低氧暴露训练(1次/d、210 min/次),模拟海拔高度从3000 m递增至4500 m.供氧组急进高原后前10d,对受试者实施渐进式低氧暴露方案:白天活动期间,宿舍内采用弥散式供氧,氧浓度22％～25％,等效生理高度2600～3500 m;夜晚睡眠期间,利用睡眠氧帐进行供氧,氧浓度25％～27％,等效生理高度2000～2600 m;对照组不采取任何措施.比较3组人员在不同情况下的血氧饱和度(arterial oxygen saturation,SaO2)和睡眠情况. 结果 ①在3600 m模拟海拔高度检测,预习服组通过10 d训练后SaO2明显高于训练前(t=3.66,P=0.035).②3组受试者睡眠总时间、深睡时间和SaO2比较差异有统计学意义(F=16.253～70.865,P＜0.01)；预习服组和供氧组睡眠总时间、深睡时间和SaO2均明显高于对照组(t=2.22～7.88,P＜0.05或P＜0.01). 结论 进驻高原前进行渐进式间歇性低氧预习服训练和急进高原后进行渐进式低氧暴露均可提高缺氧耐力,促进高原低氧习服.Objective To compare the acclimatization effects of progressively intermittent hypoxia training before entering plateau,progressive hypoxia exposure after entering plateau and natural acclimatization.Methods Twelve healthy subjects were averagely divided into training group,oxygensupply group and control group according to different plateau entering methods.Training group ascended to the simulated high altitude in a normal hypobaric chamber 210 min a day for 10 days before entering plateau,and the altitude was progressively varied from 3000 m to 4500 m.Oxygen-supply group was implemented progressive hypoxic exposures in the first 10 days of entering plateau.The gas dispersion (O2 concentration:22 ％-25 ％,physiological equivalent height:2600-3500 m) was respectively applied in dormitory during the daytime and in the oxygen fed sleep tent (O2 concentration:25％-27％,physiological equivalent height:2000-2600 m) at night.Control group entered and stationed in plateau with natural acclimatization.The arterial oxygen saturation (SaO2) and sleep condition were compared among 3 groups.Results ①Compared with that before training,the SaO2 of training group was significantly increased at simulated 3600 m by 10 day training (t=3.66,P=0.035).②There were significant differences on total sleep time,deep sleep time and SaO2 among 3 groups (F=16.253-70.865,P＜0.01).For the first 10 d of entry the total sleep time,deep sleep time and SaO2 of training group and oxygen-supply group were significantly higher than those of control group (t=2.22-7.88,P＜0.05 or P＜0.01).Conclmions Both ways of progressively intermittent hypoxia training before entering plateau and progressive hypoxia exposures after entering plateau can increase person's hypoxia intolerance and improve altitude acclimatization.

关 键 词：高海拔 缺氧 环境暴露 习服 

分 类 号：R594.3[医药卫生—内科学]