脾肾通瘀饮联合ACEI对原发性局灶节段性肾小球硬化患者尿CTGF的影响  

Effect of Pishen Tongyu Yin Combined with ACEI on Urinary CTGF Level in Patients with Primary Focal Segmental Glomerulosclerosis

作　　者：严晓华[1] 金一顺[1] 蓝健姿[1] 黄昉萌[1] 张雪梅[1] 

机构地区：[1]福建医科大学省立临床医学院,福建福州350003

出　　处：《福建中医药大学学报》2013年第6期6-8,共3页Journal of Fujian College of Traditional Chinese Medicine

基　　金：福建省卫生厅重点课题(WZZSB0931)

摘　　要：目的探讨脾肾通瘀饮治疗原发性局灶节段性肾小球硬化的作用机制。方法将60例患者数字随机分为脾肾通瘀饮联合ACEI和单纯ACEI组,分别治疗2个月,比较2组患者24 h尿蛋白定量、肾功能及尿CTGF水平变化。结果 2组均能减少尿蛋白、尿CTGF,脾肾通瘀饮联合ACEI组降低程度优于对照组(P<0.01)。结论脾肾通瘀饮可能通过减少尿蛋白,阻断CTGF表达,抑制肾脏纤维化,延缓FSGS病情进展。Objective To explore the mechanism of Pishen Tongyu Yin in treating primary focal segmental glomerulosclerosis(FSGS). Methods 60 patients were randomly assigned to Pishen Tongyu Yin combined with ACEI group and ACEI group, and the two groups received corresponding treatment for 2 months. Then the quantitation of 24 hours urinary protein, renal function and change of urinary CTGF level of patients in the two groups were compared. Results The levels of 24 hours urinary protein and urinary CTGF were decreased respectively in the two groups, and the decreasing amplitude of the two indexes in Pishen Tongyu Yin combined with ACEI group was higher than that in ACEI group, and there was a significant difference between them(P<0.01). Conclusion Pishen Tongyu Yin could inhibit renal fibrosis, delay FSGS progression by reducing urinary protein and blocking CTGF expression.

关 键 词：脾肾通瘀饮 ACEI FSGS 24 h尿蛋白定量 尿CTGF 

分 类 号：R692.3[医药卫生—泌尿科学]