射干地龙颗粒对鸡的亚慢性毒性试验  被引量:3

Study on Subchronic Toxicity of Shegan Dilong Particles in Chicken

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作  者:王贵波[1] 王东升[1] 谢家声[1] 郑继方[1] 罗超应[1] 李锦宇[1] 罗永江 辛蕊华 李晓蓉[3] 

机构地区:[1]中国农业科学院兰州畜牧与兽药研究所,兰州730050 [2]农业部兽用药物创制重点实验室,兰州730050 [3]甘肃省农业科学院畜草与绿色农业研究所,兰州730070

出  处:《湖北农业科学》2013年第4期878-882,共5页Hubei Agricultural Sciences

基  金:国家科技支撑计划项目(2011BAD34B03);甘肃省科技支撑项目(1104NKCA094)

摘  要:为研究射干地龙颗粒的安全性,将120只21日龄的三黄肉鸡,随机分为3倍剂量组、6倍剂量组、12倍剂量组和对照组,观察射干地龙颗粒对鸡的心、肝、脾、肺、肾脏和血液等组织的影响。结果表明,各组鸡的体重、脏器指数以及血常规指标组间差异总体不显著(P>0.05),血清丙氨酸氨基转移酶活性及肌酐含量与药物剂量间呈现无规律性变化,白蛋白含量和尿素含量与对照组差异不显著(P>0.05)。在用药后,各组鸡的心、肝、脾、肺和肾脏均无明显差异,表现正常。In order to evaluate the safety of Shegan Dilong particles,120 21-day-old Sanhuang broilers were randomly divided into four groups including the 3-fold dose group,6-fold dose group,12-fold dose group and the control group.The impact on the chicken’s heart,liver,spleen,lung,kidney and blood were observed.The results showed that the difference of overall weight,organ index and blood indicators in each group of chicken was not significant(P>0.05),while there was no regularity between the serum alanine aminotransferase activity,creatinine concentration and drug dosage of each group while the content of albumin and urea had no significant differences compared with the control group(P>0.05).After administration,the performance of chicken’s heart,liver,spleen,lung and kidney were not significantly different from normal in all groups.

关 键 词:射干地龙颗粒  亚慢性毒性 生理生化指标 

分 类 号:S[农业科学]

 

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