中性粒细胞杀灭病原体的新途径:胞外诱捕网  

A new strategy for eliminating invading microbes by neutrophil: extracellular traps

作　　者：吴腾飞[1] 陈福广[2] 黄清华[2] 陈伟[2] 邓旭明[2] 张巧灵[2] 刘波[2] 

机构地区：[1]中国医科大学实验动物学部,沈阳110001 [2]吉林大学畜牧兽医学院,长春130062

出　　处：《免疫学杂志》2013年第2期173-176,共4页Immunological Journal

基　　金：国家自然基金(30972170);科学前沿与交叉学科创新项目(200903337);平台基地建设项目(450060445321)

摘　　要：中性粒细胞是天然免疫系统中到达感染部位并清除微生物的第一道免疫防线的主要成员之一。已证实中性粒细胞存在3种杀灭微生物的途径:吞噬清除病原体、分泌抗微生物蛋白颗粒和新近发现的中性粒细胞诱捕网(neutrophil extracellular traps,NETs)。NETs由解聚的染色体网状结构和镶嵌其中的抗微生物颗粒蛋白组成,绑定并杀灭多种微生物,包括细菌、真菌、寄生虫和病毒。中性粒细胞通过释放DNA网状结构,形成抗微生物感染的物理屏障和支架结构,限制病原的活动范围,增强抗微生物蛋白的协同作用,并减少对宿主的组织损伤。Neutrphils as main members in the innate immune response are recruited to infection sites and form the first line of defense.Neutrophils have bee proved to employ three major antimicrobial strategies: engulfment and subsequent elimination of microbes,releasing antimicrobial molecules,and the recently described release of neutrophil extracellular traps(NETs).NETs are composed of decondensed chromatin and antimicrobial proteins,which bind and kill a variety of microbes including bacteria,parasites and fungi.The web-like NETS structure may contribute to microbial containment by forming a physical barrier and a scaffold,to enhance antimicrobial synergy while minimizing damage to host tissues.

关 键 词：中性粒细胞 胞外诱捕网 病原微生物 

分 类 号：R392.12[医药卫生—免疫学]