外泌体与结核分枝杆菌相互作用的研究进展  

Progress of the interaction between Exosomes and M. tuberculosis

作　　者：陈偲[1] 王建军[1] 汤立军[1] 

机构地区：[1]中南大学生物科学与技术学院分子生物学研究中心,长沙410078

出　　处：《免疫学杂志》2013年第2期177-179,共3页Immunological Journal

基　　金：国家自然科学基金项目(81071326);中南大学研究生教育教学改革研究项目(2012jg30)

摘　　要：结核病是目前世界各国重点防控传染性疾病之一。外泌体(exosomes)是多种细胞分泌的一种含有特异性与非特异性蛋白成分的囊泡结构,是机体免疫细胞之间重要的信息传递介质,其在机体免疫反应中发挥着重要作用。外泌体能呈递表面抗原,激活多种细胞免疫因子,介导巨噬细胞杀伤结核杆菌的细胞免疫反应。外泌体与结核分枝杆菌相互作用研究已经成为当前重大研究热点,有望开发成预防结核病的新型疫苗。Tuberculosis(TB) is a kind of infectious disease,of which many countries focus on prevention and control at present.Exosome secreted by cells is a kind of vesicle containing the specific and non-specific protein components,which transfer between immune cells and plays a significant role in the immune response.Exosomes can present surface antigen and activate a variety of cellular immune factors for improving macrophage’s capacity of killing Mycobacterium tuberculosis.The interaction between exosomes and Mycobacterium tuberculosis has become a major research interest at present.And new vaccines in this field are developed to prevent tuberculosis.

关 键 词：外泌体 结核分枝杆菌 巨噬细胞 疫苗 

分 类 号：R392.12[医药卫生—免疫学]