宁夏地区先天性心脏病影响因素的病例对照研究  

A Case-control Study on Influencing Factors of Congenital Heart Disease in Neonates in Ningxia

作　　者：张涛[1] 黄河[1] 李正直[1] 

机构地区：[1]宁夏医科大学,银川750004

出　　处：《宁夏医科大学学报》2013年第6期683-686,共4页Journal of Ningxia Medical University

摘　　要：目的探讨宁夏地区先天性心脏病相关的危险因素,为制定该地区先天性心脏病的预防措施提供科学依据。方法采用1:1匹配的病例对照研究,将经各种临床检查确诊患有先天性心脏病的新生儿的母亲作为病例组,按照1:1匹配选择出生时间相差不超过1个月、相同性别的健康儿童母亲作为对照,剔除不能配合完成问卷调查者。利用自行设计的调查问卷采集孕母孕前及孕期各种可疑危险因素信息。对可疑危险因素利用单因素和多因素Logistic回归进行分析。结果单因素和多因素Logistic回归分析结果均显示:孕早期发热(OR=15.63)、母亲孕前BMI≥25(OR=10.27)、梅毒检测试验阳性(OR=10.18)、孕前6个月内服避孕药(OR=6.73)、汉族(OR=4.00)是先天性心脏病的危险因素。结论要积极做好预防工作,针对孕早期发热、母亲孕前BMI高、孕前6个月内服避孕药和孕早期发热等危险因素采取干预措施,以降低先天性心脏病的发生率。Objective To explore the risk factors associated with congenital heart disease in Ningxia,and to provide scientific basis for preventive measures suitable for the region.Methods A 1:1 matched case-control study of congenital heart disease was conducted.Mothers of the newborns with congenital heart disease diagnosed by a variety of clinical examination were included as the case group while each case was matched with one mother of the healthy newborn control by gender and birth date(with difference less than one month). The mother unable to be completed with the questionnaire was excluded.Each cases and controls’direct parent were retrospectively interviewed with the same self-designed questionnaire to investigate the possible risk factors before and during mother pregnancy for congenital heart disease.Risk factors were determined using uni- variate and multivariable conditional logistic regression analysis.Results Both univariate and multivariable conditional logistic regression analysis showed that fever during first trimester of pregnancy(OR = 15.63), mothers with higher body mass index before pregnancy(OR = 10.27 ),syphilis infection(OR = 10.18 ),maternal exposure to contraceptive before pregnancy(OR =6.73),Han ethnic group(OR =4.00) were the risk factors of congenital heart disease.Conclusion Preventive work should be carried out actively.Interventive measures must be did to against the risk factors such as mothers with higher body mass index,maternal exposure to contraceptive before pregnancy,fever and maternal syphilis infection for reducing the incidence of congenital heart disease.

关 键 词：先天性心脏病 影响因素 病例对照研究 匹配 

分 类 号：R725.4[医药卫生—儿科]