13例重症手足口病患儿心电图、血清心肌酶联合脑电图改变的临床分析  

Clinical analysis of changes of ECG, serum myocardial enzyme combined with EEG from 13 children with severe hand-foot-mouth disease

作　　者：张慧文[1] 

机构地区：[1]南华大学附属第二医院功能检查科,湖南衡阳421001

出　　处：《江苏实用心电学杂志》2013年第2期570-572,共3页Journal of Practical Electrocardiology JS

基　　金：湖南省研究生科研创新基金资助项目(CX2010D380)

摘　　要：目的探讨手足口病患儿心电图、血清心肌酶联合脑电图改变的特点及临床意义。方法收集13例确诊为重症手足口病患儿,入院2～12h内行常规12导心电图、血清心肌酶谱、心肌肌钙蛋白及16导脑电图检查。结果治疗前,所有患儿心电图异常11例,以窦性心动过速、ST-T改变及房室传导阻滞、房性期前收缩为多见;心肌酶谱(谷草转氨酶、乳酸脱氢酶、肌酸激酶、肌酸激酶同工酶)异常10例;肌钙蛋白全部高于正常上限值;脑电图界限性6例,异常7例。治疗后,所有患儿的病情均有不同程度的好转或治愈。结论重症手足口病患儿大多存在心肌损害及中枢神经系统受累,应及早行心电图、心肌酶谱联合脑电图的检测,以便能够采取积极的治疗,对疗效观察、预后评价有着重要的临床应用价值。Objective To investigate the characteristics and clinical significance of the electrocardiogram, serum myocardial enzyme combined with electroencephalogram (EEG) from children with hand-foot-mouth disease(HFMD). Methods 13 children with severe HFMD were enrolled in the study. 12 lead ECG, serum myocardial enzymes, cardiac troponin and 16 lead EEG were performed within 2-12 h. Results Among all patients before treatment, 11 cases were with abnormal ECG, mostly sinus tachycardia, ST-T change,atrioventricular block, atrial premature contraction; 10 cases were with abnormal myocardial enzymes (aspartate aminotransferase, lactate dehydrogenase, creatine kinase and creatine kinase isoenzyme); all patients′ cardiac troponin values were higher than the normal upper limit values; 6 cases were with EEG boundaries and 7 cases were with abnormal EEG. After treatment, all patients had improvement in different degrees or were cured. Conclusion Children with severe HFMD mostly had myocardial damage and central nervous system involvement. ECG, myocardial enzymes and EEG detection should be done earlier in order to take active treatment promptly, which has important clinical application value for the observation of curative effect and prognosis evaluation.

关 键 词：手足口病 心电图 血清心肌酶 脑电图 

分 类 号：R54[医药卫生—心血管疾病]