罗哌卡因和丁卡因对周围神经功能影响的比较  

The comparasion of the influence on peripheral nerve function between Ropivacaine and Tetracaine

作　　者：文婷[1] 刘佳 

机构地区：[1]南昌大学第一附属医院麻醉科,南昌330006 [2]江西省精神病院检验科,南昌330029

出　　处：《江西医药》2013年第5期377-378,426,共3页Jiangxi Medical Journal

基　　金：江西省卫生厅科技计划项目(20113033)

摘　　要：目的比较等效剂量的罗哌卡因和丁卡因对周围神经功能的影响。方法成年SD大鼠36只,体质量408g-438g,随机分为6组(n=6):R1-3组和A1-3组。各组大鼠随机选取一侧臂丛神经,分别注入0.25%、0.5%、1%罗哌卡因1ml,0.25%、0.5%、1%丁卡因0.5ml。另一侧注射生理盐水,5d后,测定神经复合动作电位最大振幅和传导速度。结果与同体对照侧相比,R3组和A2-3组注射侧臂丛神经复合动作电位最大振幅均明显下降,神经传导速度减慢(P<0.05);罗哌卡因组和丁卡因组,两组组内比较:随着给药浓度的提高复合动作电位最大振幅依次降低,神经传导速度减慢(P<0.05);等效剂量相同浓度的罗哌卡因和丁卡因比较:罗哌卡因组臂丛神经复合动作电位的最大振幅较高,神经传导速度加快(P<0.05)。结论罗哌卡因对大鼠周围神经功能的影响比丁卡因更小。Objective To compare the influence on the equivalent dose of Ropivacaine and Tetracaine on peripheral nerve function.Methods 36 adult SD rats,weighing 408g-438g,were randomly divided into 6 groups(n=6):R1-3 group and A1-3 group.Rats in each group were randomly selected one side of the brachial plexus,were injected 0.25%,0.5%,1% Ropivacaine 1ml,0.25%,0.5%,1% Tetracaine 0.5ml.Another side injected equivalent amount saline,5 days later,measure the maximum amplitude and conduction velocity of nerve compound action potential.Results Compared with the controled side of the same body,the maximum amplitude of injected side brachial nerve compound action potentials in R3 group and A2-3 group were significantly decreased,and nerve conduction velocity slowed down.(P&lt;0.05);the comparison group between Ropivacaine and Tetracaine,with the increase of dosage drug concentration,the maximum amplitude of compound action potentials successively decreased,and nerve conduction velocity slowed down.(P&lt;0.05);comparision between the equivalent dose the same concentration of Ropivacaine and Tetracaine,the maximum amplitude of brachial nerve compound action potential in ropivacaine group was higher,and nerve conduction speed up(P&lt;0.05).Conclusion Ropivacaine’s influence is smaller than Tetracaine on the function of rat peripheral nerve.

关 键 词：丁卡因 罗哌卡因 周围神经 动作电位 

分 类 号：R9[医药卫生—药学]