盐酸右美托咪定对机械通气患者镇静的效果与安全性  

Effect and security of dexmedetomidine in ventilated patients sedation

作　　者：张磊[1] 石斌[2] 李斌[1] 侯启亮[1] 张志刚[1] 

机构地区：[1]兰州大学第一医院重症医学科,甘肃兰州730000 [2]上海市松江区中心医院急诊危重病科,上海201600

出　　处：《兰州大学学报（医学版）》2013年第4期58-60,64,共4页Journal of Lanzhou University（Medical Sciences）

摘　　要：目的探讨盐酸右美托咪定对机械通气患者的镇静效果与安全性。方法将56例需机械通气的患者随机分为盐酸右美托咪定组(A组)、咪达唑仑组(B组)和丙泊酚组(C组)。记录镇静前的序贯器官衰竭估计评分、Ramsay评分和氧分压/吸氧浓度指标。记录镇静中4、8、12h的心率、血压和呼吸。镇静达12 h时停止药物输注,每60 min评估1次镇静深度,记录恢复时间、达到满意镇静深度的时间、镇静满意程度。结果盐酸右美托咪定有良好的镇静效果,同时对呼吸没有抑制,停药后患者有较好的恢复时间,但是相比咪达唑仑及丙泊酚有轻度的心血管抑制反应(P<0.05)。结论盐酸右美托咪定对机械通气患者镇静有独特优势,可推广于临床运用。Objective To explore the sedative effects and security of dexmedetomidine on ventilated patients vs midazolam or propofol.Methods 56 ventilated patients were divided into dexmedetomidine group(group A),midazolam group(group B),propofol group(group C).Recorded the sequential organ failure assessment,ramsay score and partial pressure of oxygen/oxygen concentration index indicators before sedation.Heart rate,blood pressure and respiration were recorded at 4,8 and 12 h of sedation.The infusion was ceased after 12 h,then the sedative degree was assessed every 60 min,and recovery time,time to achieve satisfactory sedation and the sedation level were recorded.Results Dexmedetomidine could achieve a good sedative effect,and had no suppression for respiration.After infusion,the recovery time was good.But it had cardiovascular adverse effects(P <0.05).Conclusion Dexmedetomidine has peculiar advances for ventilated patients,so its use should be generalized with watching security.

关 键 词：盐酸右美托咪定 机械通气 镇静 

分 类 号：R614[医药卫生—麻醉学]