硫酸头孢匹罗合成工艺路线  

Synthetic Technologies of Cefpirome sulfate

作　　者：倪福震 

机构地区：[1]华北制药河北华民药业有限责任公司,河北石家庄052165

出　　处：《煤炭与化工》2013年第7期31-33,81,共4页Coal and Chemical Industry

摘　　要：硫酸头孢匹罗为第4代头孢菌素,临床效果好。综述了硫酸头孢匹罗适合工业化的2种合成方法,即以7-氨基头孢烷酸(7-ACA)为原料合成方法和以7-苯乙酰胺基-3-碘甲基头孢烷酸对甲氧基苄酯(GCLE)为原料合成方法。指出以7-氨基-3-乙烯基头孢烷酸(7-ACA)为原料合成方法成本低、反应速度快、产率高,更适合工业化生产,今后应继续对其工艺进行深入研究。Cefpirome sulfate,one of the fourth generation cephalosporins, has good clinical effects. Two kinds of synthetic technologies of cefpirome sulfate were summaried,those were with 7-amino-cephalosporanic acid(7-ACA)as material and with 7- acetophenone amide-3- methyl iodide cephalosporanic acid p-methoxybenzyl ester(GCLE)as material. It was pointed out that the synthetic technology with 7-ACA as material had some characteristics of low cost, fast reaction speed, high yield and more suitable for industrial production, so the technology should be further studied.

关 键 词：硫酸头孢匹罗 头孢匹罗 合成 工艺 7-ACA GCLE 综述 

分 类 号：TQ465[化学工程—制药化工]