野生竹节参和雪莲及其细胞培养产物的抗缺氧作用观察  

Anti-hypoxia effect of wild Panax Japonicus C.A. Mey and Saussurea and their products in cell culture medium

作　　者：周湘洁 王亮[2] 牛东滨[2] 郭志刚[3] 

机构地区：[1]总装备部后勤部航天城门诊部,北京100094 [2]总装备部航天医学工程研究所 [3]清华大学化工系,北京100084

出　　处：《总装备部医学学报》2010年第3期129-132,共4页Medical Journal of General Equipment Headquarters

摘　　要：目的观察比较野生竹节参和雪莲及其细胞培养产物的常压抗缺氧作用。方法制备野生竹节参、竹节参细胞培养产物、野生天山雪莲、西藏雪莲细胞培养产物含药饲料,以密闭常压缺氧小鼠为实验动物模型,尼莫地平为阳性药物,观察比较上述两种中药及其细胞培养产物的常压抗缺氧作用。结果延长小鼠缺氧生存时间的效果为:尼莫地平组>竹节参细胞培养产物组>野生竹节参组>野生天山雪莲组>西藏雪莲细胞培养产物组。结论在野生竹节参和雪莲及其细胞培养产物中,竹节参细胞培养产物的常压抗缺氧作用最强。Objective To observe the effect of anti-hypoxia of wild Panax Japonicus.C.A.Mey and Saussurea and their products in cell culture medium. Methods Mice with normal baric hypoxia were used as an animal model of acute hypoxia;the mice injected with nimodipine as positive control group,while the mice with wild Panax Japonicus.C.A.Mey,wild Saussurea,cell culture products of wild Panax Japonicus.C.A.Mey and wild Saussurea as experimental groups,respectively.The survival time of mouse in each group was observed under normal baric hypoxia. Results The sequence of prolonging survival time of hypoxia was nimodipine group,group with cell culture product of wild Panax Japonicus.C.A.Mey,group with wild Panax Japonicus.C.A.Mey,group with wild Saussurea and group with cell culture product of wild Saussurea in turn. Conclusion The cell culture product of wild Panax Japonicus.C.A.Mey has the strongest effect of anti-hypoxia in the experimental groups.

关 键 词：竹节参 雪莲 细胞培养产物 抗缺氧作用 

分 类 号：R282.71[医药卫生—中药学]