槲皮素磷酸酯钾对血小板激活时钙流动的影响(英文)  

EFFECTS OF POTASSIUM QUERCETIN PHOSPHATE ON CALCIUM MOVEMENT OF ACTIVATED PLATELET

作　　者：杜文民[1] 汤允昭[2] 王志平[2] 张轩萍[2] 

机构地区：[1]上海市药品不良反应监测中心,中国200040 [2]山西医科大学药理教研室

出　　处：《中国医学生物技术应用》2002年第1期35-38,共4页The Chinese Academic Medical Magazine of Organisms

摘　　要：目的:研究槲皮素磷酸酯钾对血小板激活时钙流动的影响 方法:用荧光钙离子指示剂Fura-2观察槲皮素磷酸酯钾对血小板胞浆游离钙的影响。结果:槲皮素磷酸酯钾明显抑制凝血酶诱导的血小板游离钙的升高,减低细胞外钙内流,对细胞内储钙释放和非特异性钙内渗无影响。结论:抑制钙内流是槲皮素磷酸酯钾抑制血小板激活时胞浆[Ca2+]I 升高和抑制血小板功能的机制。AIM: To study the effects of PQP on calcium movement of activated platelet METHODS: Using Fura-2 fluorescence technique. RESULTS: PQP inhibited the rise of [Ca2+]i induced by thrombin in platelets. This is because that PQP reduced the influx of extracellular calcium. But PQP had no effect on thrombin-induced internal Ca2+ release from dense tubular system and extracellular calcium non-specific endosnosis. CONCLUSION: The inhibitory effect of PQP on the rise of [Ca2+]i in platelets was mainly due to an inhibition of Ca2+ influx.

关 键 词：槲皮素磷酸酯钾 凝血酶 血小板 钙 

分 类 号：R96[医药卫生—药理学]