MRI测量胎儿肺体积在评估先天性膈疝预后中的价值  

The Value of Using Magnetic Resonance Imaging to Measure the Fetal Lung Volume in Prenatal Prognosis of Congenital Diaphragmatic Hernia

作　　者：祝菁[1] 杨祖菁[1] 刘明[1] 孙琦[1] 

机构地区：[1]上海交通大学医学院附属新华医院,上海200092

出　　处：《中国产前诊断杂志（电子版）》2012年第1期8-11,共4页Chinese Journal of Prenatal Diagnosis(Electronic Version)

摘　　要：目的讨论使用MRI测量胎儿肺体积在产前评估先天性膈疝胎儿预后中的价值。方法使用MRI分别测量病例组(先天性膈疝胎儿14例)和对照组(正常胎儿32例)的肺体积(TFLV)大小。根据测得的正常胎儿肺体积大小得到回归方程,并计算先天性膈疝胎儿的实际肺体积占预测肺体积的百分比(o/eTFLV),分析其与先天性膈疝胎儿预后之间的关系。结果存活的先天性膈疝胎儿与死亡胎儿相比有更高的TFLV和o/eTFLV,二者差异有统计学意义(P=0.026,P=0.025);o/eTFLV≥35%的先天性膈疝胎儿预后好于o/eTFLV<35%者,且差异有统计学意义(P=0.031)。结论使用MRI测量先天性膈疝胎儿肺体积大小、计算o/eTFLV值,对于产前评估胎儿肺发育并判断其预后有较大的作用。Objective To discuss the value of using magnetic resonance imaging(MRI)to measure the fetal lung volume in prenatal prognosis of congenital diaphragmatic hernia(CDH).Method The total fetal lung volume(TFLV)of 14CDH cases and 32normal cases were measured by magnetic resonance imaging (MRI).We got the regression formula based on the data of normal total fetal lung volume.We used the formula to estimate TFLV of CDH cases basing on gestational age,calculated o/e TFLV and discussed the relationship between o/e TFLV and the survival of CDH.Results The survival CDH fetuses had higher value of TFLV(P=0.026)and o/e TFLV(P=0.025)than those were not survival CDH fetuses,which had statistical significance.The prognosis of CDH fetuses whose o/e TFLV≥35% was better than those o/e TFLV<35%(P=0.031)and the result had statistical significance.Conclusions The using of MRI measurement of TFLV and o/e TFLV of CDH fetuses had a high value of prenatal prognosis fetal lung development and survival of CDH fetuses.

关 键 词：先天性膈疝 胎儿肺体积 MRI 产前评估 

分 类 号：R714.53[医药卫生—妇产科学]