孕妇血栓前状态对胎儿生长受限及新生儿结局的影响  

Effects of Thrombophilia on Fetal Growth Restriction and Fetal Outcome

作　　者：陈晖[1] 姜立新[1] 雷艳爱[1] 

机构地区：[1]广东省江门市人民医院产科,广东江门529000

出　　处：《中国产前诊断杂志（电子版）》2013年第3期29-31,共3页Chinese Journal of Prenatal Diagnosis(Electronic Version)

摘　　要：目的研究孕妇血栓前状态对胎儿生长受限(fetal growth restriction,FGR)及新生儿结局的影响。方法观察2010年1月至2012年12月在本院按期产检、无合并症的第一胎孕妇共732人,发现胎儿生长受限(FGR)42例,自愿接受低分子肝素治疗的患者11例为研究1组;继续观察并在本院分娩的14例为研究2组;同期正常分娩孕妇14例为对照组。比较:①各组孕28~32周、36周及分娩前凝血功能,包括红细胞压积(HCT)、血小板计数(PLT)、凝血酶原时间(PT)、部分凝血活酶时间(APTT)、凝血酶时间(TT);②新生儿出生孕周及体重。结果①孕32周:研究1组血小板计数(PLT)明显低于对照组,P=0.004,P【0.05,差异有统计学意义;②孕36周:研究1组血小板计数(PLT)与研究组无差异,但明显低于研究2组,P=0.014,P【0.05;研究1组治疗后与对照组凝血酶原时间(PT)比较有明显差异,有统计学意义,P=0.045,P【0.05;③分娩前:各组间凝血功能无明显差异;④组内比较分娩前与孕32周:研究1组P=0.054,研究2组PLT增加有明显差异性,P=0.046,P【0.05;⑤各组新生儿胎龄无明显差异,P=0.22,P=0.23,P=0.81,P】0.05。各组出生体重比较有明显差异,P=0.002,P=0.033,P=0.002,P【0.05。结论①FGR孕妇在孕28~32周前已存在有血栓前状态,导致胎儿宫内生长减缓,低体重儿出生;②低分子肝素治疗可改善FGR患者的血栓前状态,可改善新生儿的妊娠结局。Objective To explore the effects of thrombophilia on fetal growth restriction(FGR)and newborn outcome.Method 11cases of FGR enrolled in low-molecular-heparin were in group 1.14cases of FGR in study group 2.14cases normal pregnant women were in control group 3.Monitor in 32weeks,36weeks and the time before labor:Hematocrit(HCT),blood platelet(PLT),Activated panialthrombopalstin time(APTT),Plasma prothrombin time(PT),Thrombin time(TT);birth weight and embryo age.Results ①32weeks:The number of PLT in group 1is lower than group 3,P=0.004.②36weeks: PT in group 1is longer than in group 3,P=0.014.③ There were no differences in three groups at the time before labor.④Compare 32-weeks with the time before labor:PLT had risen up.Group 1,P=0.054.Group 2,P=0.046.Group 3,P=0.34.⑤ The gestationalage had no difference in three groups.The newborn weight have significantly difference,P=0.002,P=0.033,P=0.002,P<0.05.Conclusions ①Effects of thrombophilia on fetal growth restriction had been existed before 28~32weeks,and can conduce low birth weight.2.Low-molecular-heparin can increase the birth weight.

关 键 词：胎儿生长受限 低分子肝素 血栓前状态 妊娠结局 

分 类 号：R714.51[医药卫生—妇产科学]