Glycemic control indicators in patients with neonatal diabetes mellitus  

作　　者：Shigeru Suzuki Masafumi Koga 

机构地区：[1]Department of Pediatrics, Asahikawa Medical University [2]Department of Internal Medicine, Kawanishi City Hospital

出　　处：《World Journal of Diabetes》2014年第2期198-208,共11页世界糖尿病杂志（英文版）（电子版）

摘　　要：Neonatal diabetes mellitus(NDM) is a type of diabetes mellitus caused by genetic abnormality which devel ops in insulin dependent state within 6 mo after birth HbA1c is widely used in clinical practice for diabetes mellitus as the gold standard glycemic control indica tor; however, fetal hemoglobin(HbF) is the main he moglobin in neonates and so HbA1c cannot be used as a glycemic control indicator in NDM. Glycated albumin(GA), another glycemic control indicator, is not affected by HbF. We reported that GA can be used as a glycemic control indicator in NDM. However, it was later found that because of increased metabolism of albumin, GA shows an apparently lower level in relation to plasma glucose in NDM; measures to solve this problem were needed. In this review, we outlined the most recen findings concerning glycemic control indicators in neo nates or NDM.Neonatal diabetes mellitus(NDM) is a type of diabetes mellitus caused by genetic abnormality which devel ops in insulin dependent state within 6 mo after birth HbA1c is widely used in clinical practice for diabetes mellitus as the gold standard glycemic control indica tor; however, fetal hemoglobin(HbF) is the main he moglobin in neonates and so HbA1c cannot be used as a glycemic control indicator in NDM. Glycated albumin(GA), another glycemic control indicator, is not affected by HbF. We reported that GA can be used as a glycemic control indicator in NDM. However, it was later found that because of increased metabolism of albumin, GA shows an apparently lower level in relation to plasma glucose in NDM; measures to solve this problem were needed. In this review, we outlined the most recen findings concerning glycemic control indicators in neo nates or NDM.

关 键 词：Glycemic control HBA1C Glycated ALBUMIN FRUCTOSAMINE 1 5-ANHYDROGLUCITOL NEONATAL diabetes MELLITUS 

分 类 号：R722.1[医药卫生—儿科]