interrelationships between ghrelin, insulin and glucose homeostasis: physiological relevance  

作　　者：FranCois Chabot Alexandre Caron Mathieu Laplante David H St-Pierre 

机构地区：[1]Département de Kinanthropologie, Université du Québec à Montréal [2]Department of Anatomy and Physiology, Institut universitaire de cardiologie et de pneumologie de Québec

出　　处：《World Journal of Diabetes》2014年第3期328-341,共14页世界糖尿病杂志（英文版）（电子版）

基　　金：Supported by Fonds de Recherche du Québec en Santé(toLaplante M and St-Pierre DH);Operating grants from NaturalSciences and Engineering Research Council of Canada and Diabète Québec;Laplante M also holds operating grants from the Canadian Institutes of Health Research,Canadian Liver Foundation and the Fondation de l’Institut Universitaire de Cardiologieet de Pneumologie de Québec

摘　　要：Ghrelin is a 28 amino acid peptide mainly derived from the oxyntic gland of the stomach. Both acylated(AG) and unacylated(UAG) forms of ghrelin are found in the circulation. Initially, AG was considered as the only bioactive form of ghrelin. However, recent advances indicate that both AG and UAG exert distinct and common effects in organisms. Soon after its discovery, ghrelin was shown to promote appetite and adiposity in animal and human models. In response to these anabolic effects, an impressive number of elements have suggested the influence of ghrelin on the regulation of metabolic functions and the development of obesityrelated disorders. However, due to the complexity ofits biochemical nature and the physiological processes it governs, some of the effects of ghrelin are still debated in the literature. Evidence suggests that ghrelin influences glucose homeostasis through the modulation of insulin secretion and insulin receptor signaling. On the other hand, insulin was also shown to influence circulating levels of ghrelin. Here, we review the relationship between ghrelin and insulin and we describe the impact of this interaction on the modulation of glucose homeostasis.Ghrelin is a 28 amino acid peptide mainly derived from the oxyntic gland of the stomach. Both acylated(AG) and unacylated(UAG) forms of ghrelin are found in the circulation. Initially, AG was considered as the only bioactive form of ghrelin. However, recent advances indicate that both AG and UAG exert distinct and common effects in organisms. Soon after its discovery, ghrelin was shown to promote appetite and adiposity in animal and human models. In response to these anabolic effects, an impressive number of elements have suggested the influence of ghrelin on the regulation of metabolic functions and the development of obesityrelated disorders. However, due to the complexity ofits biochemical nature and the physiological processes it governs, some of the effects of ghrelin are still debated in the literature. Evidence suggests that ghrelin influences glucose homeostasis through the modulation of insulin secretion and insulin receptor signaling. On the other hand, insulin was also shown to influence circulating levels of ghrelin. Here, we review the relationship between ghrelin and insulin and we describe the impact of this interaction on the modulation of glucose homeostasis.

关 键 词：Acylated ghrelin Unacylated ghrelin Insulin secretion β-cell functions Insulin receptor signalling Glucose homeostasis 

分 类 号：R587.1[医药卫生—内分泌]