Quality of life in patients with chronic anal fissure after topical treatment with diltiazem  

作　　者：Akira Tsunoda Yasuharu Kashiwagura Ken-ichi Hirose Tadanori Sasaki Nobuyasu Kano 

机构地区：Department of Surgery,Kameda Medical Center,Chiba 296-8602,Japan Department of Pharmacy Services,Kameda Medical Center,Chiba 296-8602,Japan

出　　处：《World Journal of Gastrointestinal Surgery》2012年第11期251-255,共5页世界胃肠外科杂志（英文版）（电子版）

基　　金：Supported by The Department of Pharmacy Services,Kameda Medical Center Foundation

摘　　要：AIM: To assess the physical and mental health of fissure patients before and after topical treatment with diltiazem. METHODS: Consecutive patients were enrolled prospectively into the study. Quality of life was measured with the short-forum 36 health survey (SF-36) before and after 6-wk treatment with diltiazem. Patients scored symptoms of pain, bleeding, and irritation using numeral rating scales at the initial and follow-up visits. Fissure healing was assessed and side effects were noted. RESULTS: Fissures healed in 21 of 30 (70%) patients. There were significant reductions in the scores of pain, bleeding, and irritation after 1 wk of treatment, respectively. Four patients experienced perianal itching and one patient reported headache. When measured at baseline, pain and irritation showed a negative impact on two of the eight subscales on the SF-36, respectively (bodily pain and social functioning for pain; vitality and mental health for irritation). Repeating the SF-36 showed an improvement in bodily pain (P = 0.001). Patients whose fissures healed reported an improvement in bodily pain, health-perception, vitality, and mental health (P < 0.05). CONCLUSION: Successful treatment of chronic anal fissure with topical diltiazem leads to improvement in health-related quality of life. AIM:To assess the physical and mental health of fissure patients before and after topical treatment with diltiazem.METHODS:Consecutive patients were enrolled prospectively into the study.Quality of life was measured with the short-forum 36 health survey(SF-36) before and after 6-wk treatment with diltiazem.Patients scored symptoms of pain,bleeding,and irritation using numeral rating scales at the initial and follow-up visits.Fissure healing was assessed and side effects were noted.RESULTS:Fissures healed in 21 of 30(70%) patients.There were significant reductions in the scores of pain,bleeding,and irritation after 1 wk of treatment,respectively.Four patients experienced perianal itching and one patient reported headache.When measured at baseline,pain and irritation showed a negative impact on two of the eight subscales on the SF-36,respectively(bodily pain and social functioning for pain;vitality and mental health for irritation).Repeating the SF-36 showed an improvement in bodily pain(P = 0.001).Patients whose fissures healed reported an improvement in bodily pain,health-perception,vitality,and mental health(P &lt; 0.05).CONCLUSION:Successful treatment of chronic anal fissure with topical diltiazem leads to improvement in health-related quality of life.

关 键 词：Anal fissure Quality of life DILTIAZEM 

分 类 号：R657.1[医药卫生—外科学]