Alcoholic pancreatitis:A tale of spirits and bacteria  

作　　者：Alain Vonlaufen Laurent Spahr Minoti V Apte Jean-Louis Frossard 

机构地区：[1]Gastroenterology Unit,Hopital de la Tour [2]Department of Gastroenterology,University Hospital [3]Pancreatic Research Group,South Western Sydney Clinical School,The Ingham Institute [4]Faculty of Medicine,The University of New South Wales

出　　处：《World Journal of Gastrointestinal Pathophysiology》2014年第2期82-90,共9页世界胃肠病理生理学杂志（英文版）（电子版）

摘　　要：Alcohol is a major cause of chronic pancreatitis.About5%of alcoholics will ever suffer from pancreatitis,suggesting that additional co-factors are required to trigger an overt disease.Experimental work has implicated lipopolysaccharide,from gut-derived bacteria,as a potential co-factor of alcoholic pancreatitis.This review discusses the effects of alcohol on the gut flora,the gut barrier,the liver-and the pancreas and proposes potential interventional strategies.A better understanding of the interaction between the gut,the liver and the pancreas may provide valuable insight into the pathophysiology of alcoholic pancreatitis.Alcohol is a major cause of chronic pancreatitis.About5%of alcoholics will ever suffer from pancreatitis,suggesting that additional co-factors are required to trigger an overt disease.Experimental work has implicated lipopolysaccharide,from gut-derived bacteria,as a potential co-factor of alcoholic pancreatitis.This review discusses the effects of alcohol on the gut flora,the gut barrier,the liver-and the pancreas and proposes potential interventional strategies.A better understanding of the interaction between the gut,the liver and the pancreas may provide valuable insight into the pathophysiology of alcoholic pancreatitis.

关 键 词：Alcohol PANCREATITIS Fibrosis BACTERIA ENDOTOXIN LIPOPOLYSACCHARIDE 

分 类 号：R657.51[医药卫生—外科学]