非诺贝特固体分散体制备工艺研究及比较  

Comparison of different technologies in the preparation of fenofibrate solid dispersion

作　　者：郑杨[1] 张志丽[2] 王立红[2] 礼彤[2] 郭永学[2] 周丽莉[2] 

机构地区：[1]沈阳药科大学高等职业技术学院 [2]沈阳药科大学制药工程学院

出　　处：《中国药剂学杂志（网络版）》2012年第2期26-34,共9页Chinese Journal of Pharmaceutics：Online Edition

摘　　要：目的以不同方法制备难溶性药物非诺贝特固体分散体并进行工艺比较。方法采用物理混合法、熔融法、溶剂法、超临界流体技术制备非诺贝固体分散体,用体外累计溶出度及差式扫描量热法判定不同方法制备固体分散体的差别。结果超临界流体技术制备的非诺贝特固体分散体,溶出速率显著提高,累计溶出量最大,60min药物累计溶出达到93.49%。结论超临界流体技术制备非诺贝特固体分散体优于常用方法。Objective To prepare fenofibrate solid dispersion by using different methods and optimize preparation process.Methods Solid dispersion of fenofibrate was prepared by using melting,solvent and supercritical fluid(SCF) methods,respectively.Properties of the solid dispersion prepared by different methods were characterized using dissolution rate and differential scanning calorimetry technique.Results It was found that the dissolution rate from solid dispersion prepared using supercritical fluid method was significantly improved,with 93.49% fenofibrate release at 60 min..Conclusion The SCF process is superior for the preparation of solid dispersion than melting and solvent methods.

关 键 词：药剂学 固体分散体 超临界流体 熔融法 溶剂法 非诺贝特 

分 类 号：TQ463.2[化学工程—制药化工]