α-细辛脑静脉注射乳剂在大鼠体内的药动学研究  

Pharmacokinetics study of α-asarone intravenous emulsion in rats

作　　者：王媛媛[1] 王淑君[1] 

机构地区：[1]沈阳药科大学药学院

出　　处：《中国药剂学杂志（网络版）》2012年第2期39-44,共6页Chinese Journal of Pharmaceutics：Online Edition

摘　　要：目的比较细辛脑静脉注射乳剂与细辛脑注射剂的体内药动学行为。方法以市售细辛脑注射剂为对照,大鼠尾静脉注射给药,测定大鼠体内血浆中药物浓度,并进行数据处理和分析。结果大鼠单剂量注射细辛脑静脉注射乳剂和注射剂后,其平均血药质量浓度-时间曲线相似,受试制剂与参比制剂的AUC分别为342.79mg·L-1·min-1和368.28mg·L-1·min-1。结论细辛脑静脉注射乳剂与静脉注射剂注射后的血药浓度相似,两者生物等效。Objective To compare the pharmacokinetics of α-asarone intravenous emulsion and aqueous solution for injection.Methods HPLC was used to determine the drug concentration in rat plasma after intravenous administration of emulsion and solution of α-asarone.The pharmacokinetic parameters were calculated using DAS 2.0 software.Result The plasma concentration-time profiles of emulsion and solution of α-asarone were similar after intravenous administration.Conclusion The plasma concentration-time profiles of α-asarone in emulsion and solution were similar,two preparations were bioequivalent.

关 键 词：药剂学 注射乳剂 药动学 Α-细辛脑 

分 类 号：R285.5[医药卫生—中药学]