聚丙交酯乙交酯共聚物作为大分子药物载体的纳米及微米技术研究进展  

Nano and micro technologies for delivering macromolecular therapeutics using poly(lactide-co-glycolide)

作　　者：王玉[1] 王东凯[1] 孙念[1] 

机构地区：[1]沈阳药科大学药学系

出　　处：《中国药剂学杂志（网络版）》2009年第3期205-211,共7页Chinese Journal of Pharmaceutics：Online Edition

摘　　要：目的介绍聚丙交酯乙交酯共聚物(poly(lactide-co-glycolide,PLGA)纳米粒和微粒的研究概况及其在大分子药物传递方面的应用。方法查阅国内外有关文献并进行综合分析。结果PLGA具有良好的生物相容性和生物降解性,已被广泛的应用于蛋白质、多肽等大分子药物的载体。结论将PLGA与其他物质混合或者对PLGA进行结构修饰,改善PLGA的性质,可提高其作为药物载体的能力。PLGA纳米粒和微粒是很有前景的大分子药物载体,值得进一步的研究和完善。Objective To introduce the current application of poly(lactide-co-glycolide)(PLGA) nanoparticles or microparticles as the carriers of macromolecules.Method To review the related literatures comprehensively.Result PLGA and PLGA-based polymers are biocompatibile and biodegradable, and have been widely explored as carriers for the delivery of macromolecular therapeutics such as proteins, peptides.Conclusion PLGA can be blended with other adjuncts or modified to improve its property as drug carriers.PLGA nanoparticles or microparticles are promising carriers for the delivery of macromolecular therapeutics.

关 键 词：药剂学 药物载体 综述 聚丙交酯乙交酯共聚物纳米粒 聚丙交酯乙交酯共聚物微粒 大分子 

分 类 号：R94[医药卫生—药剂学]