氟比洛芬有机原位凝胶的制备及体外释放行为的考察  

Preparation and in vitro release of in situ organogel of flurbiprofen

作　　者：贾强[1] 王可可[1] 韩飞[1] 刘洪卓[1] 李三鸣[1] 

机构地区：[1]沈阳药科大学药学院

出　　处：《中国药剂学杂志（网络版）》2009年第5期365-371,共7页Chinese Journal of Pharmaceutics：Online Edition

基　　金：国家自然科学基金项目(30772670)

摘　　要：目的制备氟比洛芬有机原位凝胶并考察其体外释放行为。方法通过对凝胶因子、抗凝剂的用量等因素的考察,制备氟比洛芬有机原位凝胶。建立氟比洛芬有机原位凝胶的体外分析方法,考察凝胶中各组分对其释放的影响。结果制备了氟比洛芬有机原位凝胶,并确定氟比洛芬有机原位凝胶的最优处方。抗凝剂的种类及用量是影响氟比洛芬有机原位凝胶体外释放的主要因素,凝胶因子的用量对氟比洛芬有机原位凝胶体外释放的影响不大。结论氟比洛芬有机原位凝胶能延长药物的释放时间,是一种新型药物剂型。Objective To prepare and characterize the in situ organogel in vitro. Methods The in situ organogel of flurbiprofen was prepared by investigating the amounts of LAM and anti-gelling solvents. In vitro analytical method of in situ forming organogel of flurbiprofen was established, and influence of each ingredient on the release of flurbiprofen from the in situ forming organogel was investigated in a shaking water bath. Results The optimum formulation of flurbiprofen in situ forming organogel was confirmed. The type and amount of anti-gelling solvent had significant influence on the in vitro release. In contrast, the amount of gelator had only marginal influence on the in vitro release. Conclusions In situ forming organogel is a new dosage form and could release flurbiprofen in a sustained manner.

关 键 词：药剂学 氟比洛芬 有机原位凝胶 制备 体外释放 

分 类 号：R94[医药卫生—药剂学]